14-3-3τ/θ, pAb

[KCIP-1, Protein kinase C inhibitor protein 1, HS1 protein, T cell protein]



BML-SA481-0025	25 µl	87.00 USD

BML-SA481-0100	100 µl	303.00 USD

Replaces Prod. #: ALX-215-028

Product Specification

Formulation:	Liquid. Neat serum containing sodium azide.

Immunogen:	Acetylated N-terminal epitope of 14-3-3 tau/theta.

Source/Host:	From rabbit.

Specificity:	Recognizes human, mouse, rat, cow and sheep 14-3-3τ/θ.

Application:	Immunohistochemistry (1:60) Western Blot (1:3’000) Optimal condition must be determined individually for each application.

Shipping:	SHIPPED ON BLUE ICE

Long Term Storage:	-20°C

Background / Technical Information:	Please click here for the comprehensive product datasheet.

Western blot analysis of rat brain cell extracts probed with anti-14-3-3τ/θ antibody BML-SA481 (1:3’000). Developed by HRP/ECL with 10 sec. exposure.

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General Literature References

Antibodies against the major brain isoforms of 14-3-3 protein. An antibody specific for the N-acetylated amino-terminus of a protein. H. Martin et al. FEBS Lett. 331 296 (1993) Abstract

Purification of 14-3-3 protein and analysis of isoforms in chicken brain. Y. Patel et al. Biochim. Biophys. Acta. 1222 405 (1994) Abstract

Subcellular localisation of 14-3-3 isoforms in rat brain using specific antibodies. H. Martin et al. J. Neurochem. 63 2259 (1994) Abstract

14-3-3 alpha and delta are the phosphorylated forms of raf-activating 14-3-3 beta and zeta. In vivo stoichiometric phosphorylation in brain at a Ser-Pro-Glu-Lys MOTIF. A. Aitken et al. J. Biol. Chem. 270 5706 (1995) Abstract

Expression and structural analysis of 14-3-3 proteins. D.H. Jones et al. J. Mol. Biol. 245 375 (1995) Abstract

Isoforms of 14-3-3 protein can form homo- and heterodimers in vivo and in vitro: implications for function as adapter proteins. D.H. Jones et al. FEBS Lett. 368 55 (1995) Abstract

Identification of 14-3-3 proteins in human platelets: effects of synthetic peptides on protein kinase C activation. C.P. Wheeler-Jones et al. Biochem. J. 315 41 (1996) Abstract

Neurofibrillary tangles of Alzheimer’s disease brains contain 14-3-3 proteins. R. Layfield et al. Neurosci. Lett. 209 57 (1996) Abstract

14-3-3 inhibits the Dictyostelium myosin II heavy-chain-specific protein kinase C activity by a direct interaction: identification of the 14-3-3 binding domain. M. Matto-Yelin et al. Mol. Biol. Cell 8 1889 (1997) Abstract

The structural basis for 14-3-3:phosphopeptide binding specificity. M.B. Yaffe et al. Cell 91 961 (1997) Abstract

Isoform pattern of 14-3-3 proteins in the cerebrospinal fluid of patients with Creutzfeldt-Jakob disease. J. Wiltfang et al. J. Neurochem. 73 2485 (1999) Abstract

Functional specificity in 14-3-3 isoform interactions through dimer formation and phosphorylation. Chromosome location of mammalian isoforms and variants. A. Aitken Plant Mol. Biol. 50 993 (2002) Abstract

Immunolocalisation of 14-3-3 isoforms in normal and scrapie-infected murine brain. H.C. Baxter et al. Neuroscience 109 5 (2002) Abstract

Interaction of Akt-phosphorylated ataxin-1 with 14-3-3 mediates neurodegeneration in spinocerebellar ataxia type 1. H-K. Chen et al. Cell 113 457 (2003) Abstract

Mammalian and yeast 14-3-3 isoforms form distinct patterns of dimers in vivo. M. Chaudhri et al. Biochem. Biophys. Res. Commun. 300 679 (2003) Abstract

Novel brain 14-3-3 interacting proteins involved in neurodegenerative disease. S. Mackie & A. Aitken FEBS J. 272 4202 (2005) Abstract

Unchanged survival rates of 14-3-3gamma knockout mice after inoculation with pathological prion protein. P. Steinacker et al. Mol. Cell Biol. 25 1339 (2005) Abstract