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2-Methoxyestradiol

Estrogen receptor inhibitor
 
BML-S540-0010 10 mg 74.00 USD
 
BML-S540-0050 50 mg 307.00 USD
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An endogenous estrogen metabolite with low affinity for the estrogen receptor but which disrupts microtubule function. Potent inhibitor of endothelial cell proliferation and migration. Inhibits bFGF and VEGF-induced corneal neovascularization in mice. Posttranscriptionally downregulates HIF-1α expression.

Product Specification

Alternative Name:2-ME
 
Formula:C19H26O3
 
MW:302.4
 
CAS:362-07-2
 
Purity:≥95% (TLC)
 
Identity:Determined by 1H-NMR and MS.
 
Appearance:White solid.
 
Shipping:Ambient
 
Long Term Storage:Ambient
 
BML-S540 structure
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BML-S540 structure

Product Literature References

To complete its replication cycle, a shrimp virus changes the population of long chain fatty acids during infection via the PI3K-Akt-mTOR-HIF1α pathway: Y.C. Hsieh, et al.; Dev. Comp. Immunol. 53, 85 (2015), Application(s): Injection into shrimp, Abstract;
Evidence for the interplay between JNK and p53-DRAM signalling pathways in the regulation of autophagy: S. Lorin, et al.; Autophagy 6, 153 (2010), Abstract;

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