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Deoxymannojirimycin . HCl

Mannosidase inhibitor
 
BML-S109-0005 5 mg 146.00 USD
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Replaces Prod. #: ALX-580-002

Potent inhibitor of α-mannosidase I. Blocks the biosynthesis of complex-type oligosaccharides. Does not inhibit the biosynthesis of lipid-linked oligosaccharides. Induces ER stress in human cells.

Product Specification

Formula:C6H13NO4 . HCl
 
MW:199.6
 
CAS:84444-90-6
 
Purity:≥98% (TLC)
 
Identity:Determined by 1H-NMR.
 
Appearance:White solid.
 
Solubility:Soluble in water, methanol (warm) and DMSO.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
BML-S109 structure
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BML-S109 structure

Product Literature References

1-Deoxymannojirimycin, the alpha1,2-mannosidase inhibitor, induced cellular endoplasmic reticulum stress in human hepatocarcinoma cell 7721: Y. Lu et al.; Biochem. Biophys. Res. Commun. 344, 221 (2006), Abstract;
Effect of retinyl acetate on the assembly of the fibronectin extracellular matrix and the processing of the fibronectin receptor beta subunit of confluent C3H/10T1/2 mouse embryo fibroblasts: S.S. Suzuki & L.H. Piette; J. Cell. Biochem. 51, 181 (1993), Abstract;
The use of 1-deoxymannojirimycin to evaluate the role of various alpha-mannosidases in oligosaccharide processing in intact cells: J. Bischoff et al.; J. Biol. Chem. 261, 4766 (1986), Abstract;
Inhibitors of oligosaccharide processing: U. Furhmann et al.; Biochim. Biophys. Acta 825, 95 (1985), Abstract;
Secretion of high-mannose-type alpha 1-proteinase inhibitor and alpha 1-acid glycoprotein by primary cultures of rat hepatocytes in the presence of the mannosidase I inhibitor 1-deoxymannojirimycin: V. Gross et al.; Eur. J. Biochem. 150, 41 (1985), Abstract;

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