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Castanospermine

Glucosidase inhibitor
 
BML-S107-0100 100 mg 116.00 USD
 
BML-S107-0500 500 mg 445.00 USD
Do you need bulk/larger quantities?
 
Replaces Prod. #: ALX-270-160

Plant alkaloid. Potent inhibitor of α- and β-glucosidases. Exhibits antiviral properties. Inhibits thyroglobulin secretion. Antitumor activity. Inhibits protein glycosylation. Prevents angiogenesis.

Product Specification

Formula:C8H15NO4
 
MW:189.2
 
CAS:79831-76-8
 
MI:14: 1896
 
Purity:≥95% (TLC)
 
Appearance:White to off-white crystalline solid.
 
Solubility:Soluble in water.
 
Shipping:Ambient
 
Long Term Storage:+4°C
 
Use/Stability:Stable for at least 1 year after receipt when stored at 4°C. Stock solutions are stable for for up to 3 months at -20°C.
 
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Product Literature References

LMAN1 (ERGIC-53) is a potential carrier protein for matrix metalloproteinase-9 glycoprotein secretion: T. Duellman, et al.; Biochem. Biophys. Res. Commun. 464, 385 (2015), Application(s): Cell Culture, Abstract;
Perturbation of free oligosaccharide trafficking in endoplasmic reticulum glucosidase I-deficient and castanospermine-treated cells.: C. Durrant & S.E. Moore; Biochem. J. 365, 239 (2002), Abstract;
Antiviral activity and metabolism of the castanospermine derivative MDL 28,574, in cells infected with herpes simplex virus type 2.: S.P. Ahmed, et al.; BBRC 208, 267 (1995), Abstract;
The alpha-glucosidase I inhibitor castanospermine alters endothelial cell glycosylation, prevents angiogenesis, and inhibits tumor growth.: R. Pili, et al.; Cancer Res. 55, 2920 (1995), Abstract;
Effects of the anti-inflammatory compounds castanospermine, mannose-6- phosphate and fucoidan on allograft rejection and elicited peritoneal exudates.: M.R. Bartlett, et al.; Immunol. Cell Biol. 72, 367 (1994), Abstract;
Simultaneous determination of sugar incorporation into glycosphingolipids and glycoproteins.: P. Paul, et al.; Anal. Biochem. 204, 265 (1992), Abstract;
Castanospermine vs. its 6-O-butanoyl analog: a comparison of toxicity and antiviral activity in vitro and in vivo.: R.M. Ruprecht, et al.; J. Acquir. Immune Defic. Syndr. 4, 48 (1991), Abstract;
Effects of deoxymannojirimycin and castanospermine on the polarized secretion of thyroglobulin.: J. Franc, et al.; Endocrinology 126, 1464 (1990), Abstract;
Inhibition of v-fms-induced tumor growth in nude mice by castanospermine.: G.K. Ostrander, et al.; Cancer Res. 48, 1091 (1988), Abstract;
Interference with HIV-induced syncytium formation and viral infectivity by inhibitors of trimming glucosidase.: R.A. Gruters, et al.; Nature 330, 74 (1987), Abstract;
The effects of processing inhibitors of N-linked oligosaccharides on the intracellular migration of glycoprotein E2 of mouse hepatitis virus and the maturation of coronavirus particles.: R. Repp, et al.; J. Biol. Chem. 260, 15873 (1985), Abstract; Full Text
Glycoproteins: their structure, biosynthesis and possible clinical implications.: H. Schachter; Clin. Biochem. 17, 3 (1984), Abstract;
Studies on the mechanism of castanospermine inhibition of alpha- and beta-glucosidases.: R. Saul, et al.; Arch. Biochem. Biophys. 230, 668 (1984), Abstract;
Castanospermine inhibits the processing of the oligosaccharide portion of the influenza viral hemagglutinin.: Y.T. Pan, et al.; Biochemistry 22, 3975 (1983), Abstract;

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