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Conduritol B Epoxide

Glycosidase inhibitor
 
BML-S104-0005 5 mg 59.00 USD
 
BML-S104-0025 25 mg 236.00 USD
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Replaces Prod. #: ALX-270-082

A potent, irreversible inhibitor of various plant β-glucosidases and mammalian glucocerebrosidase. Has been employed in in vitro and animal models for Gaucher’s disease. It raises intracellular levels of glucosylceramide by inhibiting glucosylceramidase.

Product Specification

Alternative Name:D,L-1,2-Anhydro-myo-inositol
 
Formula:C6H10O5
 
MW:162.1
 
CAS:6090-95-5
 
Purity:≥96% (TLC)
 
Identity:Determined by 1H-NMR and MS.
 
Appearance:White solid.
 
Solubility:Soluble in water (25mg/ml) or in DMSO.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Use/Stability:Stable for at least 1 year after receipt when stored, as supplied, at -20°C. Product must be stored under argon.
 
Handling:Hygroscopic. Protect from moisture.
 
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Product Literature References

Glucosylated cholesterol in mammalian cells and tissues: formation and degradation by multiple cellular β-glucosidases: A.R. Margues, et al.; J. Lipid Res. 57, 451 (2016), Application(s): Inhibition of GBA, Abstract; Full Text
Normalization of liver glucosylceramide levels in the "Gaucher" mouse by phosphatidylserine injection: S.C. Datta & N.S. Radin; Biochem. Biophys. Res. Commun. 152, 155 (1988), Abstract;
beta-Glucosidase inhibition in murine peritoneal macrophages by conduritol-B-epoxide: an in vitro model of the Gaucher cell: D.S. Newburg, et al.; Biochim. Biophys. Acta 877, 121 (1986), Abstract;
Destruction and resynthesis of mouse beta-glucosidases: A. Hara & N.S. Radin; Biochim. Biophys. Acta 582, 412 (1979), Abstract;
The Gaucher mouse: differential action of conduritol B epoxide and reversibility of its effects: M.C. Stephens, et al.; J. Neurochem. 30, 1023 (1978), Abstract;
Mechanism of action of glycoside-splitting enzymes. V. Labelling of the active center of beta-glucosidases A and B from sweet almond emulsin with (3H)6-bromo-6-deoxyconduritol B epoxide: G. Legler; Hoppe-Seyler's Z. Physiol. Chem. 351, 25 (1970), Abstract;

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