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USP15 (human) polyclonal antibody

BML-PW9795-0025 25 µl 110.00 USD
BML-PW9795-0100 100 µl 330.00 USD
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Product Specification

Alternative Name:Ubiquitin-specific protease 15
Immunogen:Recombinant human USP15 (aa 724-952).
UniProt ID:Q9Y4E8
Species reactivity:Human, Mouse
Formulation:Liquid. In serum containing 0.01% sodium azide as a preservative.
Shipping:Shipped on Blue Ice
Long Term Storage:-20°C
Scientific Background:Ubiquitin-specific protease 15 (USP15) contains the highly conserved Cys and His boxes present in all members of the UBP family of deubiquitinating enzymes. USP15 shares 60.5% sequence identity and 76% sequence similarity with the human homolog (UNP/Unph/USP4) of the mouse Unp proto-oncogene. USP15 can be co-purified with the human CSN complex. Detailed analysis reveals a novel Zinc (Zn)-finger in USP15 and related USPs. Mutation of a single conserved cysteine residue in the predicted Zn binding motif results in the loss of USP15 capability to degrade poly-Ub substrates, indicating that the Zn-finger is essential for the cleavage of poly-Ub chains.

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