Immunoproteasome 20S (human), (purified)

Purity Detail:	Highly purified.

Source/Host:	Isolated from human spleen.

Long Term Storage:	-80°C

Miscellaneous/General:	The eukaryotic proteasome contains 7α-type and 7 ß-type subunits. Upon stimulation with IFN-γ, the three active ß subunits, ß1 (Y), ß2 (Z) and ß5 (X) are exchanged to their immunocounterparts, namely ß1i (LMP-2), ß2i (MECL-1) and ß5i (LMP-7). This results in a change in proteasomal substrate specificity. Some groups have reported increases in chymotrypsin-like and trypsin-like activities while others have reported no changes or even decreased activities after such treatment.

Background / Technical Information:	Please click here for the comprehensive product datasheet.