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Parkin (human) polyclonal antibody

 
BML-PW9365-0025 25 µl 100.00 USD
 
BML-PW9365-0100 100 µl 356.00 USD
Do you need bulk/larger quantities?
 

Product Specification

Host:Rabbit
 
Immunogen:Synthetic peptide corresponding to aa 399-415 (CE339QARWEAASKETIK412) of human parkin. A single amino acid substitution (A405E) exists in both the rat and mouse homologues.
 
UniProt ID:O60260
 
Species reactivity:Human
 
Applications:IHC, IP, WB
 
Blocking Peptide:For Blocking peptide see Prod. No. BML-PP9365.
 
Formulation:Liquid. In PBS.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Scientific Background:Parkin is a ubiquitin-protein ligase (E3), and mutations in the Parkin gene appear to be closely associated with autosomal recessive juvenile Parkinson’s disease. Parkin has been localised to Lewy bodies in patients with sporadic Parkinson’s disease, and in peri-nuclear aggresome-like inclusions in cells over-expressing wild-type Parkin where proteasomal activity has also been inhibited4. Both types of inclusion also contain ubiquitin, α-synuclein, proteasomal subunits and heat shock proteins. A recent paper suggests that loss of proteasomal activity leads to Parkin accumulation with a concomitant reduction in E3 ligase activity resulting in Lewy body formation5.Parkin is selectively recruited from the cytosol to damaged mitochondria to trigger their autophagy (mitophagy).
 

Product Literature References

Methamphetamine oxidatively damages parkin and decreases the activity of 26S proteasome in vivo: A. Moszczynska, et al.; J. Neurochem. 116, 1005 (2011), Application(s): Immunoprecipitation and Western blot, Abstract; Full Text

General Literature References

PINK1 Is Selectively Stabilized on Impaired Mitochondria to Activate Parkin: D.P. Narenda, et al.; PLoS Biol. 8, e1000298 (2010), Abstract;
Parkin is recruited selectively to impaired mitochondria and promotes their autophagy: D. Narendra, et al.; J.Cell.Biol. 183, 795 (2008), Abstract;

Related Products

Blocking peptide for Parkin (human) pAb (Prod. No. BML-PW9365) 

≥95% | Print as PDF
 
BML-PP9365-0100 100 µg 32.00 USD
Do you need bulk/larger quantities?
 

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