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Valosin-containing protein polyclonal antibody

 
BML-PW9335-0025 25 µl 100.00 USD
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Product Specification

Alternative Name:VCP, Transitional endoplasmic reticulum ATPase, TER ATPase
 
Host:Rabbit
 
Immunogen:Synthetic peptide corresponding to aa 20-37 of the human VCP sequence.
 
UniProt ID:P55072
 
Species reactivity:Human, Mouse, Rat
Porcine
 
Applications:WB
 
Blocking Peptide:For Blocking peptide see Prod. No. BML-PP9350.
 
Formulation:Liquid. Antiserum containing 10mM sodium azide.
 
Handling:Avoid freeze/thaw cycles.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Scientific Background:Valosin containing protein (VCP) is an abundant and a highly conserved member of the family of ATPases. Besides acting as a chaperone in membrane fusions, VCP is now recognized as a multi-ubiquitin chain-targeting factor that is required in the degradation of many ubiquitin-proteasome pathway substrates. p97/VCP is likely important in regulating both UPS- and autophagy-mediated protein degradation. This places p97/VCP in a key regulatory position at the intersection of these two proteolytic pathways.
 

General Literature References

Valosin-containing protein (VCP) is required for autophagy and is disrupted in VCP disease: J.S. Ju, et al.; J.Cell.Biol. 187, 875 (2009), Abstract;

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