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Proteasome 20S β5i subunit polyclonal antibody

BML-PW8400-0100 100 µl Inquire for pricing
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Product Specification

Alternative Name:Proteasome subunit β type-8, LMP7, RING10 protein, Macropain subunit C13
Immunogen:KLH-conjugated synthetic peptide derived from human LMP7.
UniProt ID:P28062
Gene/Protein Identifier:PSMB8 (gene name), 5696 (Entrez Gene ID)
Species reactivity:Human, Mouse, Rat
Bovine, Dog
Specificity:Recognizes the β5i subunit of the 20S proteasome.
Applications:ELISA, IF, IHC (PS), WB
Recommended Dilutions/Conditions:ELISA (1:500-1,000)
Immunofluorescence (1:50-200)
Immunohistochemistry (paraffin sections, 1:100-500)
Western Blot (1:100-500)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
Purity Detail:Purified by Protein A and peptide affinity chromatography
Formulation:Liquid. In buffer containing 100µg/ml BSA, 50% glycerol and 0.09% sodium azide.
Shipping:Shipped on Blue Ice
Long Term Storage:-20°C
Scientific Background:The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. This gene is located in the class II region of the MHC (major histocompatibility complex). Expression of this gene is induced by gamma interferon and this gene product replaces catalytic subunit 3 (proteasome beta 5 subunit) in the immunoproteasome. Proteolytic processing is required to generate a mature subunit. Two alternative transcripts encoding two isoforms have been identified; both isoforms are processed to yield the same mature subunit.

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