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p53 (human) monoclonal antibody (EX-3)

 
BML-PW1115-0025 25 µg 170.00 USD
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Product Specification

Alternative Name:TRP53, Tumor protein p53
 
Clone:EX-3
 
Host:Mouse
 
Isotype:IgG2a
 
Immunogen:Recombinant full length human p53.
 
UniProt ID:P04637
 
Species reactivity:Human
 
Specificity:Recognizes an N-terminal epitope of p53.
 
Applications:WB
 
Formulation:Liquid. In PBS containing 0.09% sodium azide.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-80°C
 
Scientific Background:p53 is a much studied and complex multifunctional protein, which plays a major role in the cellular response to DNA damage and other genomic aberrations. The activation of p53 can lead to either cell cycle arrest and DNA repair, or apoptosis, through its involvement in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for these processes. Activation and regulation of the p53 transcription pathway is controlled by a range of post-translational modifications including acetylation, phosphorylation, ubiquitinylation and SUMOylation.
 

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