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USP19 polyclonal antibody

 
BML-PW1025-0025 25 µl 108.00 USD
 
BML-PW1025-0100 100 µl 356.00 USD
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Product Specification

Alternative Name:ZMYND9, Zinc finger MYND domain-containing protein 9
 
Host:Rabbit
 
Immunogen:Recombinant fragment of human USP19 (aa 1-129).
 
UniProt ID:O94966
 
Species reactivity:Human, Mouse, Rat
 
Applications:WB
 
Recommended Dilutions/Conditions:Western Blot (1:100)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
 
Purity Detail:Immunoaffinity purified.
 
Formulation:Liquid. In 100mM TRIS, pH 7.0 containing 100mM glycine and 0.02% sodium azide.
 
Use/Stability:Stable for at least 1 year after receipt when stored as recommended.
 
Handling:Do not freeze.
 
Shipping:Blue Ice Not Frozen
 
Long Term Storage:+4°C
 
Scientific Background:The deubiquitinylating enzyme USP19 is induced in skeletal muscle atrophy in response to numerous catabolic stimuli, including cancer, fasting, diabetes, and glucocorticoids. Loss of USP19 interferes with the growth of L6 myoblasts through its modulation of the transcription of major myofibrillar proteins.

USP19 regulates cell growth, partly through indirect control of p27Kip1 degradation in the G1 phase of the cell cycle. Since a number of cancers are associated with enhanced degradation of p27Kip1, the overexpression of USP19 may also be a pathogenetic mechanism of the disordered cell growth in cancer and a potential novel therapeutic target for its treatment.

In addition USP19 has been shown to be a tail anchored DUB, localised to the ER, suggesting a role in the turnover of ERAD substrates and to be targeted by the unfolded protein response.

USP19 is expressed in a wide range of tissues and is localised to the cytoplasm and endoplasmic reticulum.
 
BML-PW1025
Figure: Detection of full length USP19 and its degradation fragments in mouse testis lysate (50µg) by Western blot using USP19, pAb (Prod. No. BML-PW1025) (1:100).
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BML-PW1025

General Literature References

The ER-resident ubiquitin-specific protease 19 participates in the UPR and rescues ERAD substrates: G.C. Hassink, et al.; EMBO Rep. 10, 755 (2009), Abstract;
USP19 deubiquitinating enzyme supports cell proliferation by stabilizing KPC1, a ubiquitin ligase for p27Kip1: Y. Lu, et al.; Mol. Cell Biol. 29, 547 (2009), Abstract;
USP19-deubiquitinating enzyme regulates levels of major myofibrillar proteins in L6 muscle cells: P. Sundaram, et al.; Am. J. Physiol. Endocrinol. Metab. 297, E1283 (2009), Abstract;
USP19 is a ubiquitin-specific protease regulated in rat skeletal muscle during catabolic states: L. Combaret, et al.; Am. J. Physiol. Endocrinol. Metab. 288, E693 (2005), Abstract;

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