United States
USP19, pAb
| BML-PW1025-0025 | 25 µl | 92.00 USD |  |
||
| BML-PW1025-0100 | 100 µl | 325.00 USD | |
||
Product Specification
| Alternative Name: | ZMYND9, Zinc finger MYND domain-containing protein 9 |
| Purity Detail: | Immunoaffinity purified. |
| Formulation: | Liquid. In 100mM TRIS, pH 7.0 containing 100mM glycine and 0.02% sodium azide. |
| Immunogen: | Recombinant fragment of human USP19 (aa 1-129). |
| Source/Host: | From rabbit. |
| Specificity: | Recognizes human, mouse and rat USP19. |
| Application: | Western Blot (1:100) Optimal conditions must be determined individually for each application. |
| Long Term Storage: | +4°C |
| Use/Stability: | Stable for at least 1 year after receipt when stored as recommended. |
| Handling: | Do not freeze. |
| Miscellaneous/General: | The deubiquitinylating enzyme USP19 is induced in skeletal muscle atrophy in response to numerous catabolic stimuli, including cancer, fasting, diabetes, and glucocorticoids. Loss of USP19 interferes with the growth of L6 myoblasts through its modulation of the transcription of major myofibrillar proteins. USP19 regulates cell growth, partly through indirect control of p27Kip1 degradation in the G1 phase of the cell cycle. Since a number of cancers are associated with enhanced degradation of p27Kip1, the overexpression of USP19 may also be a pathogenetic mechanism of the disordered cell growth in cancer and a potential novel therapeutic target for its treatment. In addition USP19 has been shown to be a tail anchored DUB, localised to the ER, suggesting a role in the turnover of ERAD substrates and to be targeted by the unfolded protein response. USP19 is expressed in a wide range of tissues and is localised to the cytoplasm and endoplasmic reticulum. |
| Background / Technical Information: | UniProt ID O94966: USP19 (human) |
Figure: Detection of full length USP19 and its degradation fragments in mouse testis lysate (50µg) by Western blot using USP19, pAb (Prod. No. BML-PW1025) (1:100).
Please mouse over
General Literature References
The ER-resident ubiquitin-specific protease 19 participates in the UPR and rescues ERAD substrates: G.C. Hassink, et al.; EMBO Rep. 10, 755 (2009), Abstract;
USP19 deubiquitinating enzyme supports cell proliferation by stabilizing KPC1, a ubiquitin ligase for p27Kip1: Y. Lu, et al.; Mol. Cell Biol. 29, 547 (2009), Abstract;
USP19-deubiquitinating enzyme regulates levels of major myofibrillar proteins in L6 muscle cells: P. Sundaram, et al.; Am. J. Physiol. Endocrinol. Metab. 297, E1283 (2009), Abstract;
USP19 is a ubiquitin-specific protease regulated in rat skeletal muscle during catabolic states: L. Combaret, et al.; Am. J. Physiol. Endocrinol. Metab. 288, E693 (2005), Abstract;
Product Toolbox
PRODUCT RESOURCES
Datasheet
RELATED PRODUCTS
By catalog section:
By biological activity:
USP Polyclonal antibodyPRODUCT SUPPORT
Technical ServiceBulk Quantity Quote
Customer Service
Related Literature
TOPIX Newsletters
TOPIX IV/10 - Product Newsletter from Enzo Life Sciences
Add to order list
 |
04-Oct-10 |
| Download as PDF | |
