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Proteasome 19S Rpt2/S4 subunit (human) polyclonal antibody

BML-PW0530-0025 25 µl 110.00 USD
BML-PW0530-0100 100 µl 363.00 USD
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Product Specification

Alternative Name:Proteasome 26S subunit ATPase 1, 26S protease regulatory subunit 4
Immunogen:Synthetic peptide corresponding to aa 368-383 of human proteasome 19S (Rpt2/S4 subunit).
UniProt ID:P62191
Species reactivity:Human
Recommended Dilutions/Conditions:Western Blot (1:1,000)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
Purity Detail:Partially purified by salt precipitation.
Formulation:Liquid. In PBS containing 0.01% sodium azide.
Use/Stability:Stable for at least 1 year after receipt when stored at -20°C. Dilute with PBS, pH 7.2-7.4, containing 1% normal goat serum (if a goat anti-rabbit IgG linker antibody is to be used). Store diluted antibody at +4°C, do not freeze and use within 1 month.
Handling:Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
Shipping:Shipped on Blue Ice
Short Term Storage:+4°C
Long Term Storage:-20°C
Scientific Background:The 19S regulatory complex consists of a ‘base’ sub-complex, composed of a hetero-hexameric ring of AAA-ATPases that not only function as the gate-opener to the 20S proteasome but also, in conjunction with two other high-molecular-mass non-ATPase subunits (Rpn2/S1 and Rpn1/S2), as a platform for protein unfolding. The ‘lid’ sub-complex of the 19S complex, composed of non-ATPase subunits is involved in the binding and deubiquitinylation of proteasome targeted ubiquitin conjugated proteins and assists in the transport of substrates through the ‘base’ and into the 20S catalytic core.
Figure: Western blot showing detection of Rpt2/S4 19S regulatory subunit. Lane 1: Purified 26S proteasome (Prod. No. BML-PW9310, 1µg). Lane 2: HeLa S100 cytosolic fraction (Prod. No. BML-SW8750, 10µg). PAb to Proteasome 19S (Rpt2/S4 Subunit) (human) (Prod. No. BML-PW0530) at 1:1’000 dilution.
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General Literature References

Depletion of 26S proteasomes in mouse brain neurons causes neurodegeneration and Lewy-like inclusions resembling human pale bodies: L. Bedford, et al.; J. Neurosci. 28, 8189 (2008), Abstract;

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