Replaces Prod. #: BML-PW0505
Product Details
| Alternative Name: | Sentrin-1, Small ubiquitin-related modifier 1 |
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| Host: | Rabbit |
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| Immunogen: | Full length recombinant human SUMO-1. |
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| UniProt ID: | P63165 |
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| Source: | Purified from rabbit serum. |
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| Species reactivity: | Human
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| Crossreactivity: | Species cross-reactivity expected to be high due to conservation of SUMO sequence. |
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| Applications: | ICC, IP, WB
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| Purity Detail: | Protein A affinity purified. |
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| Formulation: | Liquid. In PBS containing 50% glycerol and 0.09% sodium azide. |
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| Use/Stability: | Stable for at least 1 year after receipt when stored at -20°C. Store diluted antibody at +4°C, do not freeze and use within 1 month. |
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| Handling: | Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C. |
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| Shipping: | Blue Ice |
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| Short Term Storage: | +4°C |
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| Long Term Storage: | -20°C |
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| Scientific Background: | SUMO (small ubiquitin-related modifier) is a member of a family of ubiquitin-like proteins involved in the regulation of the cellular functions of a wide variety of proteins. Four members of the SUMO family have been described in vertebrates, SUMO-1 and the close homologues SUMO-2 and SUMO-3, with some 50% homology between SUMO-1 and SUMO-2/3. Although a fourth SUMO (SUMO-4) has been reported, there remains considerable debate as to whether this is a real and expressed gene product. |
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| Regulatory Status: | RUO - Research Use Only |
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Figure 1: Hela cells were fixed with paraformaldehyde and stained with SUMO-1 antibody (BML-PW0505A) at 1:100 dilution.
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Product Literature References
Mitochondrial MUL1 E3 ubiquitin ligase regulates Hypoxia Inducible Factor (HIF-1α) and metabolic reprogramming by modulating the UBXN7 cofactor protein: L. Cilenti, et al.; Sci. Rep.
10, 1609 (2020),
Abstract;
Full Text
SUMO Ligase Protein Inhibitor of Activated STAT1 (PIAS1) Is a Constituent Promyelocytic Leukemia Nuclear Body Protein That Contributes to the Intrinsic Antiviral Immune Response to Herpes Simplex Virus 1: J. Brown, et al.; J. Virol.
90, 5939 (2016),
Application(s): Immunofluorescence,
Abstract;
Full Text
General Literature References
A M55V polymorphism in a novel SUMO gene (SUMO-4) differentially activates heat shock transcription factors and is associated with susceptibility to type I diabetes mellitus: K.M. Bohren, et al.; J. Biol. Chem.
279, 27233 (2004),
Abstract;
SUMO, ubiquitin’s mysterious cousin: S. Muller, et al.; Nat. Rev. Mol. Cell Biol.
2, 202 (2001),
Abstract;
