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Sp100 (human) polyclonal antibody

 
BML-PW0325-0025 25 µl 118.00 USD
 
BML-PW0325-0100 100 µl 410.00 USD
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Product Specification

Host:Rabbit
 
Immunogen:Synthetic peptide corresponding to aa 292-304 of human Sp100.
 
UniProt ID:P23497
 
Species reactivity:Human
 
Specificity:Recognizes human Sp100 and SUMO modified Sp100 species.
 
Applications:ICC, WB
 
Formulation:Liquid. In PBS containing 0.01% sodium azide.
 
Handling:Avoid freeze/thaw cycles.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Scientific Background:Sp100 is an interferon-inducible protein and a major constituent of distinct nuclear domains, known as nuclear dots (NDs) or PML bodies. NDs play a role in autoimmunity, virus infections, and in the etiology of acute promyelocytic leukaemia. SUMO modification of Sp100 has been shown to promote interaction of Sp100 with non-histone chromosomal proteins, suggesting a regulatory role in chromatin organization and in functional interplay between these nuclear bodies and chromatin.
 

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