Synthetic peptide corresponding to aa 292-304 of human Sp100.
UniProt ID:
P23497
Species reactivity:
Human
Specificity:
Recognizes human Sp100 and SUMO modified Sp100 species.
Applications:
ICC, WB
Formulation:
Liquid. In PBS containing 0.01% sodium azide.
Handling:
Avoid freeze/thaw cycles.
Shipping:
Shipped on Blue Ice
Long Term Storage:
-20°C
Scientific Background:
Sp100 is an interferon-inducible protein and a major constituent of distinct nuclear domains, known as nuclear dots (NDs) or PML bodies. NDs play a role in autoimmunity, virus infections, and in the etiology of acute promyelocytic leukaemia. SUMO modification of Sp100 has been shown to promote interaction of Sp100 with non-histone chromosomal proteins, suggesting a regulatory role in chromatin organization and in functional interplay between these nuclear bodies and chromatin.
