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Cantharidic acid

PP2A inhibitor
 
BML-PR106-0010 10 mg 64.00 USD
 
BML-PR106-0050 50 mg 258.00 USD
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Replaces Prod. #: ALX-270-062

Potent and selective inhibitor of PP2A, IC50=53nM (IC50 for PP1=562nM). Useful for inhibiting PP1 and PP2A during purification of phosphorylated proteins.

Product Specification

Formula:C10H14O5
 
MW:214.2
 
CAS:28874-45-5
 
Purity:≥98% (TLC)
 
Appearance:White solid.
 
MeltingPoint:216-218°C
 
Solubility:Soluble in DMSO (25mg/ml) or ethanol (10mg/ml warm).
 
Shipping:Ambient
 
Long Term Storage:Ambient
 
Use/Stability:Store, as supplied, at room temperature for up to 5 years. Store solutions at -20°C for up to 3 months.
 
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Product Literature References

CD44 induced enhancement of phosphatase activity and calcium influx: Modifications of EGR-1 expression and cell proliferation: R.R. Racine, et al.; Biochem. Biophys. Rep. 6, 172 (2016), Application(s): Western blot and proliferation experiments,
Protein phosphatase 2A and its [3H]cantharidin/[3H]endothall thioanhydride binding site. Inhibitor specificity of cantharidin and ATP analogues: Y.M. Li, et al.; Biochem. Pharmacol. 46, 1435 (1993), Abstract;
Cantharidin-binding protein: identification as protein phosphatase 2A: Y.M. Li & J.E. Casida; PNAS 89, 11867 (1992), Abstract;

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