Sequence is calcineurin (CaN) autoinhibitory domain (rat brain CaN aa 457-482). It inhibits calcineurin with an IC50 of 10 µM using [32P]myosin light chain as substrate. Inhibits Mn2+-stimulated calcineurin activity but has no effect on Ni2+-stimulated activity. Ki=4.4 µM with radiolabeled [Ala97]-RII (81-99) peptide as the phosphatase substrate.
Product Details
| Alternative Name: | CN412 |
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| Sequence: | Ile-Thr-Ser-Phe-Glu-Glu-Ala-Lys Gly-Leu-Asp-Arg-Ile-Asn-Glu-Arg- Met-Pro-Pro-Arg-Arg-Asp-Ala-Met-Pro |
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| Formula: | C124H205N39O39S |
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| MW: | 2930.7 |
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| CAS: | 148067-21-4 |
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| Appearance: | Lyophilized solid. |
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| Solubility: | Soluble in water. |
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| Shipping: | Blue Ice |
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| Long Term Storage: | -20°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
A novel phospho-modulatory mechanism contributes to the calcium-dependent regulation of T-type Ca2+ channels: J. Chemin, et al.; Sci. Rep.
9, 15642 (2019),
Abstract;
Full Text
Steady-State Modulation of Voltage-Gated K+ Channels in Rat Arterial Smooth Muscle by Cyclic AMP-Dependent Protein Kinase and Protein Phosphatase 2B: J.L. Brignell, et al.; PLoS One
10, e0121285 (2015),
Application(s): Cell Culture,
Abstract;
Full Text
