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Calcineurin inhibitory peptide

 
BML-PR104-0500 0.5 mg 116.00 USD
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Sequence is calcineurin (CaN) autoinhibitory domain (rat brain CaN aa 457-482). It inhibits calcineurin with an IC50 of 10 µM using [32P]myosin light chain as substrate. Inhibits Mn2+-stimulated calcineurin activity but has no effect on Ni2+-stimulated activity. Ki=4.4 µM with radiolabeled [Ala97]-RII (81-99) peptide as the phosphatase substrate.

Product Specification

Alternative Name:CN412
 
Sequence:Ile-Thr-Ser-Phe-Glu-Glu-Ala-Lys Gly-Leu-Asp-Arg-Ile-Asn-Glu-Arg- Met-Pro-Pro-Arg-Arg-Asp-Ala-Met-Pro
 
Formula:C124H205N39O39S
 
MW:2930.7
 
CAS:148067-21-4
 
Appearance:Lyophilized solid.
 
Solubility:Soluble in water.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 

Product Literature References

Steady-State Modulation of Voltage-Gated K+ Channels in Rat Arterial Smooth Muscle by Cyclic AMP-Dependent Protein Kinase and Protein Phosphatase 2B: J.L. Brignell, et al.; PLoS One 10, e0121285 (2015), Application(s): Cell Culture, Abstract; Full Text

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