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Deltamethrin

Calcineurin inhibitor
 
BML-PR101-0010 10 mg 66.00 USD
 
BML-PR101-0050 50 mg 288.00 USD
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Replaces Prod. #: ALX-430-045

Synthetic type II pyrethroid. Potent calcineurin (protein phosphatase 2B) inhibitor IC50~0.03 nM. Causes an increase in neurotransmitter release at synapses and also increases intrasynaptosomal Ca2+ levels. May also have varied effects on ion channels.

Product Specification

Alternative Name:(S)-α-Cyano-(3-phenoxybenzyl (1R)-cis-3-(2,2-dibromovinyl)-2,2-dimethylcyclopropanecarboxylate
 
Formula:C22H19Br2NO3
 
MW:505.2
 
CAS:52918-63-5
 
MI:14: 2883
 
Purity:≥98% (External Standard Method)
 
Appearance:Beige solid.
 
Solubility:Soluble in DMSO (40mg/ml) or ethanol (15mg/ml, warm); insoluble in water.
 
Shipping:Ambient
 
Long Term Storage:Ambient
 
Use/Stability:Stable for at least 1 year after receipt when stored, as supplied, at room temperature. Stock solutions are stable for up to 3 months at -20°C.
 
BML-PR101 structure
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BML-PR101 structure

Product Literature References

Class II pyrethroids: noninhibitors calcineurin: A. Enz & E. Pombo-Villar; Biochem. Pharmacol. 54, 321 (1997), Abstract;
Activation of phosphoinositide/protein kinase C pathway in rat brain tissue by pyrethroids: E. Enan & F. Matsumura; Biochem. Pharmacol. 45, 703 (1993), Abstract;
Nerve membrane Na+ channels as targets of insecticides: T. Narahashi; Trends Pharmacol. Sci. 13, 236 (1992), Abstract;
Specific inhibition of calcineurin by type II synthetic pyrethroid insecticides: E. Enan & F. Matsumura; Biochem. Pharmacol. 43, 1777 (1992), Abstract;

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For Research Use Only. Not for use in diagnostic procedures.
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