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Sivelestat sodium

Elastase inhibitor
 
BML-PI157-0010 10 mg 98.00 USD
 
BML-PI157-0050 50 mg 398.00 USD
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Potent and selective leukocyte elastase inhibitor (IC50=44nM). Displays various anti-inflammatory activities including attenuation of LTB4-induced neutrophil migration and serum cytokine levels. Reduces acute inflammatory lung injury in vivo.

Product Specification

Alternative Name:ONO-5046, N-{2-[({4-[2,2-Dimethylpropanoyl)oxy]phenyl}sulfonyl)amino]benzoyl}glycine sodium salt
 
Formula:C20H21N2NaO7S . 4H2O
 
MW:528.5
 
CAS:201677-61-4
 
Purity:≥98% (HPLC)
 
Identity:Determined by NMR.
 
Appearance:White solid.
 
Solubility:Soluble in DMSO (>25mg/ml), ethanol (20mg/ml) or water (2mg/ml, warm). 
 
Shipping:Ambient
 
Long Term Storage:Ambient
 
Use/Stability:Stable for at least 1 year after receipt when stored, as supplied, at room temperature. Stock solutions are stable for up to 3 months at -20°C.
 
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Product Literature References

Neutrophil elastase inhibitor (sivelestat) reduces the levels of inflammatory mediators by inhibiting NF-kB: S. Hagiwara, et al.; Inflamm. Res. 58, 198 (2009), Abstract;
A neutrophil elastase inhibitor, sivelestat, reduces lung injury following endotoxin-induced shock in rats by inhibiting HMGB1: S. Hagiwara, et al.; Inflammation 31, 227 (2008), Abstract;
ONO-5046, a novel inhibitor of human neutrophil elastase: K. Kawabata, et al.; Biochem. Biophys. Res. Commun. 177, 814 (1991), Abstract;

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