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TAPI-0

Inhibitor of TNF-α processing
 
BML-PI133-0001 1 mg 247.00 USD
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Inhibitor of TNF-α processing. Inhibits TACE and MMPs in vitro.

Product Specification

Alternative Name:IC1, N-​[2-​[2-​(hydroxyamino)-​2-​oxoethyl]-​4-​methyl-​1-​oxopentyl]-​3-​(2-​naphthalenyl)-​L-​alanyl-​L-​alaninamide
 
Sequence:N-(R)-(2-(Hydroxyaminocarbonyl)methyl)-4-methylpentanoyl-L-naphthylalanyl-L-alanine amide
 
Formula:C24H32N4O5
 
MW:456.5
 
CAS:143457-40-3
 
Purity:≥97% (HPLC)
 
Appearance:White powder.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
BML-PI133 structure
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BML-PI133 structure

Product Literature References

Hydroxy‐Safflower Yellow A inhibits the TNFR1‐Mediated Classical NF‐κB Pathway by Inducing Shedding of TNFR1: H. Wang, et al.; Phytother. Res. 30, 790 (2016), Abstract;
A comparative study on inhibition of total astragalus saponins and astragaloside IV on TNFR1-mediated signaling pathways in arterial endothelial cells: S.Q. Liu, et al.; PLoS One. 9, e101504 (2014), Abstract; Full Text
Accelerated receptor shedding inhibits kidney injury molecule-1 (KIM-1)-mediated efferocytosis: R. Gandhi, et al.; Am. J. Physiol. Renal. Physiol. 307, F205 (2014), Abstract;
Matrix metalloproteinase-8 plays a pivotal role in neuroinflammation by modulating TNF-α activation: E.J. Lee, et al.; J. Immunol. 193, 2384 (2014), Abstract;
Overexpression of TNF-α-converting enzyme in fibroblasts augments dermal fibrosis after inflammation: S. Fukaya, et al.; Lab. Invest. 93, 72 (2013), Abstract;

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