A potent and selective cell permeable calpain inhibitor. Inhibits oxidative damage-induced apoptosis in PC12 cells and capsaicin-induced apoptosis in dorsal root ganglion neurons. It protects against anoxia in rat optic nerves and reduces neuronal damage in an animal model of global cerebral ischemia(50 mg/kg). In isolated hippocampal pyramidal neurons, it inhibits Ca2+-induced suppression of neurite outgrowth (complete inhibition at 20 µM). Calpain I Ki = 8 nM; Cathepsin B Ki = 24 nM in isolated enzyme assays. IC50 = 0.3 µM in intact cell assay.
Product Details
| Alternative Name: | N-Benzyloxycarbonylvalylphenylalaninal |
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| Sequence: | Z-Val-Phe-CHO |
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| Formula: | C22H26N2O4 |
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| MW: | 382.5 |
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| CAS: | 88191-84-8 |
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| Purity: | ≥98% (HPLC) |
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| Appearance: | White solid. |
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| Solubility: | Soluble in DMSO (200mM). |
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| Shipping: | Blue Ice |
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| Long Term Storage: | -20°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Calpain inhibitors confer biochemical, but not electrophysiological, protection against anoxia in rat optic nerves: Q. Jiang et al.; J. Neurochem.
74, 2101 (2000),
Abstract;
Oxidative stress and Ca2+ influx upregulate calpain and induce apoptosis in PC12 cells: S.K. Ray et al.; Brain Res.
852, 326 (2000),
Abstract;
D-amino acid containing, high-affinity inhibitors of recombinant human calpain I: S. Chatterjee et al.; J. Med. Chem.
41, 2663 (1998),
Abstract;
Postischemic treatment with calpain inhibitor MDL 28170 ameliorates brain damage in a gerbil model of global ischemia: P.A. Li et al.; Neurosci. Lett.
247, 17 (1998),
Abstract;
Capsaicin-induced neurotoxicity in cultured dorsal root ganglion neurons: involvement of calcium-activated proteases: P.S. Chard et al.; Neuroscience
65, 1099 (1995),
Abstract;
Calpain inhibitors block Ca(2+)-induced suppression of neurite outgrowth in isolated hippocampal pyramidal neurons.: D.K. Song et al.; J. Neurosci. Res.
39, 474 (1994),
Abstract;
