A novel substrate-based (γ-40 site) aldehyde inhibitor of γ-secretase. In whole cells overexpressing amloid ß protein precursor, Boc-GVV-CHO dose-dependently inhibited amyloid ß cleavage. γ-secretase is an important therapeutic target for strategies designed to lower amyloid ß production.
Product Details
Alternative Name: | Boc-GVV-CHO |
|
Sequence: | Boc-GVV-CHO |
|
Formula: | C17H31N3O5 |
|
MW: | 357.5 |
|
Source: | Synthetic. |
|
Purity: | ≥98% (TLC) |
|
Appearance: | White to off-white solid. |
|
Solubility: | Soluble in DMSO (>25 mg/ml) or ethanol (10 mg/ml warm). |
|
Shipping: | Ambient Temperature |
|
Long Term Storage: | -20°C |
|
Use/Stability: | Store, as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months. |
|
Regulatory Status: | RUO - Research Use Only |
|
Please mouse over