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PPACK

Thrombin inhibitor
 
BML-PI117-0005 5 mg 146.00 USD
 
BML-PI117-0025 25 mg 603.00 USD
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Replaces Prod. #: ALX-260-001

Potent irreversible thrombin inhibitor. Inhibits thrombin activation of progelatinase A. Pretreatment with PPACK inhibits thrombin-induced cerebral thromboembolism in vivo.

Product Specification

Alternative Name:D-Phe-Pro-Arg-CMK
 
Sequence:D-Phe-Pro-Arg-chloromethylketone
 
Formula:C21H31ClN6O3
 
MW:451.0
 
CAS:71142-71-7
 
Purity:≥90% (HPLC)
 
Appearance:White to off-white solid.
 
Solubility:Soluble in water.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Use/Stability:Stable for at least 1 year after receipt when stored at -20°C. Stock solutions are stable for up to 3 months at -20°C.
 
Technical Info/Product Notes:Note: Product is not sterile.
 
BML-PI117 structure
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BML-PI117 structure

Product Literature References

Thrombin promotes the expression of Ccnd1 gene in RPE cells through the activation of converging signaling pathways: I. Lee-Rivera, et al. ; Exp. Eye Res. 139, 81 (2015), Application(s): Thrombin-induced proliferation, Abstract;
Thrombin induces the activation of progelatinase A in vascular endothelial cells. Physiologic regulation of angiogenesis: S. Zucker, et al.; J. Biol. Chem. 270, 23730 (1995), Abstract;
Markers of coagulation and fibrinolysis in blood drawn into citrate with and without D-Phe-Pro-Arg-Chloromethylketone (PPACK): H.B. Rahr, et al.; Thromb. Res. 73, 279 (1994), Abstract;
Thrombin inhibitors and anti-coagulants on thrombin-induced embolisation in rabbit cranial vasculature: J.T. Liu, et al.; Eur. J. Pharmacol. 264, 183 (1994), Abstract;
D-Phe-Pro-ArgCH2C1-A selective affinity label for thrombin: C. Kettner & E. Shaw; Thromb. Res. 14, 969 (1979), Abstract;

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