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L-α-Phosphatidylinositol-3,4,5-P3 . 7Na

PKC substrate
 
BML-PH107-0100 100 µg 186.00 USD
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Replaces Prod. #: ALX-307-079

Activates Ca2+-insensitive PKC isotypes δ, ε and η. Binds to GRP1 via a PH domain.

Product Specification

Alternative Name:PtdIns(3,4,5)P3, (1,2-dipalmitoyl)-, 1,2-Dipalmitoyl-sn-glycero-3-phospho-1-D-myo-inositol-3,4,5-trisphosphate . 7Na
 
Formula:C41H75O22P4 . 7Na
 
MW:1204.8
 
Formulation:Lyophilized.
 
Purity:≥98% (TLC)
 
Solubility:Soluble in water (10mg/ml) or in chloroform/methanol/water (1:1:0.3) (>10mg/ml).
 
Shipping:Shipped on Dry Ice
 
Long Term Storage:-20°C
 
Use/Stability:Stable for at least 1 year after receipt when stored, as supplied, at -20°C. Stock solutions are stable for up to 3 months at -20°C.
 
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Product Literature References

Signaling by phosphoinositide-3,4,5-trisphosphate through proteins containing pleckstrin and Sec7 homology domains: J.K.Klarlund, et al.; Science 275, 1927 (1997), Abstract;
Activation of protein kinase C family members by the novel polyphosphoinositides PtdIns-3,4-P2 and PtdIns-3,4,5-P3: A. Toker, et al.; J. Biol. Chem. 269, 32358 (1994), Abstract;

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