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Activator of PKC and Akt
BML-PH106-0100 100 µg 164.00 USD
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Replaces Prod. #: ALX-307-038

Activates Ca2+-insensitive PKC isotypes δ, ε and η. Activates Akt/PKB by direct interaction with the Akt PH domain.

Product Specification

Formula:C41H76O19P3 . 5NH4
MW:966.0 . 90.2
Purity:≥98% (NMR)
Appearance:White solid.
Solubility:Soluble in chloroform/methanol/water, 50:50:10 (10mg/ml); not water soluble but resuspends, with vigorous vortexing, to ~0.5 mg/ml in water. See references for method of incorporation into mixed lipid vesicles by sonication, and for dissolving in a detergent-containing buffer.
Shipping:Shipped on Dry Ice
Long Term Storage:-20°C
BML-PH106 structure
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BML-PH106 structure

Product Literature References

Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate: T.F. Franke, et al.; Science 275, 665 (1997), Abstract;
Signaling by phosphoinositide-3,4,5-trisphosphate through proteins containing pleckstrin and Sec7 homology domains: J.K. Klarlund, et al.; Science 275, 1927 (1997), Application(s): Dissolving in a detergent-containing buffer., Abstract;
Activation of protein kinase C family members by the novel polyphosphoinositides PtdIns-3,4-P2 and PtdIns-3,4,5-P3: A. Toker, et al.; J. Biol. Chem. 269, 32358 (1994), Application(s): Method of incorporation into mixed lipid vesicles, Abstract;

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