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Prostaglandin H2/thromboxane A2 receptor agonist
BML-PG023-0001 1 mg 97.00 USD
BML-PG023-0010 10 mg 779.00 USD
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Replaces Prod. #: ALX-340-015

Prostaglandin H2/thromboxane A2 receptor agonist; stable analog of thromboxane A2. Induces platelet aggregation at 32nM and activates p38 MAPK.

Product Specification

Alternative Name:9,11-Dideoxy-9α,11α-methanoepoxy prostaglandin F, 9,11-Dideoxy-9α,11α-methanoepoxy prosta5Z,13E-dien-1-oic acid
Formulation:Pale yellow oil.
Purity:≥98% (HPLC-ELSD)
Solubility:Soluble in 100% ethanol, DMSO, dimethyl formamide (100mg/ml) or PBS, pH 7.2 (2mg/ml).
Shipping:Shipped on Blue Ice
Long Term Storage:-20°C
Use/Stability:Stable for at least 1 years after receipt when stored at -20°C. We do not recommend storing aqueous solutions for more than one day.
Technical Info/Product Notes:Note: Product is not sterile.
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Product Literature References

Vitamin C Deficiency Reduces Muscarinic Receptor Coronary Artery Vasoconstriction and Plasma Tetrahydrobiopterin Concentration in Guinea Pigs: G.F. Skovsted, et al.; Nutrients 9, 691 (2017), Application(s): Guinea Pig samples, Abstract; Full Text
Broad-range TRP channel inhibitors (2-APB, flufenamic acid, SKF-96365) affect differently contraction of resistance and conduit femoral arteries of rAT: M. Bencze, et al.; Eur. J. Pharmacol. 765, 533 (2015), Application(s): Induced arterial contractions, Abstract;
Ex vivo relaxations of pulmonary arteries induced by prostacyclin mimetics are highly dependent of the pre-contractile agents: C. Benyahia, et al.; Prostaglandins Other Lipid Mediat. 121, 46 (2015), Application(s): Evaluating the effects of PGI2 mimetics in rat pulmonary arteries, Abstract;
Inherited human group IVA cytosolic phospholipase A2 deficiency abolishes platelet, endothelial, and leucocyte eicosanoid generation: N.S. Kirkby, et al.; FASEB. J. 29, 4568 (2015), Abstract; Full Text
Liposomal nanoparticles encapsulating iloprost exhibit enhanced vasodilation in pulmonary arteries: P.P. Jain, et al.; Int. J. Nanomedicine 9, 3249 (2014), Abstract; Full Text
EV-077 in vitro inhibits platelet aggregation in type-2 diabetics on aspirin: K.S. Sakariassen, et al.; Thromb. Res. 130, 746 (2012), Abstract;
Mechanisms underlying increased reactivity of pulmonary arteries contralateral to a localized high-flow anastomosis: S. Pfister, et al.; J. Thorac. Cardiovasc. Surg. 141, 425 (2011), Abstract; Full Text
Salvianolic acid B and tanshinone IIA attenuate myocardial ischemia injury in mice by NO production through multiple pathways: C. Pan, et al.; Ther. Adv. Cardiovasc. Dis. 5, 99 (2011), Abstract;
Secretoneurin facilitates endothelium-dependent relaxations in porcine coronary arteries: C.K. Chan, et al.; Am. J. Physiol. Heart Circ. Physiol. 300, H1159 (2011), Abstract; Full Text
Alterations in nitric oxide and endothelin-1 bioactivity underlie cerebrovascular dysfunction in ApoE-deficient mice: K. Yamashiro, et al.; J. Cereb. Blood. Flow Metab. 30, 1494 (2010), Abstract; Full Text
Calcium-independent phospholipase A(2) plays a key role in the endothelium-dependent contractions to acetylcholine in the aorta of the spontaneously hypertensive rat.: M.S. Wong, et al.; Am. J. Physiol. Heart Circ. Physiol. 298, H1260 (2010), Abstract; Full Text
Role for p38 mitogen-activated protein kinase in platelet aggregation caused by collagen or a thromboxane analogue: J. Saklatvala, et al.; J. Biol. Chem. 271, 6586 (1996), Abstract; Full Text
Heterogeneity of thromboxane A2 (TP-) receptors: evidence from antagonist but not agonist potency measurements: P.M. Tymkewycz, et al.; Br. J. Pharmacol. 102, 607 (1991), Abstract;
Binding of a thromboxane A2/prostaglandin H2 agonist [3H]U46619 to washed human platelets: N. Liel, et al.; Prostaglandins 33, 789 (1987), Abstract;
Responsiveness of platelets and coronary arteries from different species to synthetic thromboxane and prostaglandin endoperoxide analogues: S.E. Burke, et al.; Br. J. Pharmacol. 78, 287 (1983), Abstract;
Comparison of the actions of U-46619, a prostaglandin H2-analogue, with those of prostaglandin H2 and thromboxane A2 on some isolated smooth muscle preparations: R.A. Coleman, et al.; Br. J. Pharmacol. 73, 773 (1981), Abstract;

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