Online Purchasing Account You are logged on as Guest. LoginRegister a New AccountShopping cart (Empty)
United States 

Prostaglandin A2

CDK inhibitor
 
BML-PG002-0010 10 mg 231.00 USD
Do you need bulk/larger quantities?
 
Replaces Prod. #: ALX-340-047

Blocks cell cycle at the G1 and G2/M phase [1] by inhibiting G1 phase cyclin dependent kinases [2] downregulating cyclin D1 [3]. Modulates all three aspects of the glutathione-mediated biotransformation system, i.e. GSH levels, glutathione S-transferase activity and transport of GSH conjugates [4]. Antitumor activity. Induces γ-glutamylcysteine synthetase and apoptosis in L-1210 cells.

Product Specification

Alternative Name:Medullin, Prosta-5,10,13-trien-1-oic acid, 15-hydroxy-9-oxo-, (5Z,13E,15S)-, PGA2
 
Formula:C20H30O4
 
MW:334.5
 
Source:Synthetic.
 
CAS:13345-50-1
 
Purity:≥99% (TLC)
 
Appearance:Neat oil.
 
Solubility:Soluble in 100% ethanol, acetone or ethyl acetate.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Use/Stability:Stable for at least 1 year after receipt when stored, as supplied, at -20°C.
 
Handling:Store at -20°C or colder. For experiments with cells or tissues, dissolve in ethanol and add aliquots directly to aqueous media. For HPLC, aliquots in acetone solution should be evaporated to dryness under a stream of nitrogen and HPLC mobile phase added to the desired concentration. Avoid basic conditions.
 
340-047
Please mouse over
340-047

Product Literature References

Down-regulation of cyclin D1 expression by prostaglandin A(2) is mediated by enhanced cyclin D1 mRNA turnover: S. Lin, et al.; Mol. Cell. Biol. 20, 7903 (2000), Abstract; Full Text
Interactions of prostaglandin A2 with the glutathione-mediated biotransformation system: M.L. van Iersel, et al.; Biochem. Pharmacol. 57, 1383 (1999), Abstract;
p21Waf1 inhibits the activity of cyclin dependent kinase 2 by preventing its activating phosphorylation: M. Hitomi, et al.; Oncogene 17, 959 (1998), Abstract;
Prostaglandin A2 blocks the activation of G1 phase cyclin-dependent kinase without altering mitogen-activated protein kinase stimulation: M. Hitomi, et al.; J. Biol. Chem. 271, 9376 (1996), Abstract; Full Text
Prostaglandin A2 and delta 12-prostaglandin J2 induce apoptosis in L1210 cells: I.K. Kim, et al.; FEBS Lett. 321, 209 (1993), Abstract;
Growth inhibition of Friend erythroleukaemia cell tumours in vivo by a synthetic analogue of prostaglandin A: an action independent of natural killer-activity: S. Marini, et al.; Br. J. Cancer 61, 394 (1990), Abstract;
Induction of gamma-glutamylcysteine synthetase by prostaglandin A2 in L-1210 cells: K. Ohno & M. Hirata; Biochem. Biophys. Res. Commun. 168, 551 (1990), Abstract;
Prostaglandin J2--anti-tumour and anti-viral activities and the mechanisms involved: M. Fukushima; Eicosanoids 3, 189 (1990), Abstract;

Related Literature

Brochures
Integrated solutions for screening Wnt regulators
Integrated solutions for screening Wnt regulators
Download as PDF

Product Flyers
Cell Cycle - Mitosis, CDKS & Cell Cycle Signaling
Cell Cycle - Mitosis, CDKS & Cell Cycle Signaling
Download as PDF

Technical Posters
Arachidonic Acid Metabolites
Arachidonic Acid Metabolites
Download as PDF

All new literature pieces

Recommend this page

 
For Research Use Only. Not for use in diagnostic procedures.
Keep in touch

©2017 Enzo Life Sciences, Inc.,