Replaces Prod. #: ALX-340-047
Blocks cell cycle at the G1 and G2/M phase [1] by inhibiting G1 phase cyclin dependent kinases [2] downregulating cyclin D1 [3]. Modulates all three aspects of the glutathione-mediated biotransformation system, i.e. GSH levels, glutathione S-transferase activity and transport of GSH conjugates [4]. Antitumor activity. Induces γ-glutamylcysteine synthetase and apoptosis in L-1210 cells.
Product Details
| Alternative Name: | Medullin, Prosta-5,10,13-trien-1-oic acid, 15-hydroxy-9-oxo-, (5Z,13E,15S)-, PGA2 |
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| Formula: | C20H30O4 |
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| MW: | 334.5 |
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| Source: | Synthetic. |
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| CAS: | 13345-50-1 |
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| Purity: | ≥98% (TLC) |
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| Appearance: | Neat oil. |
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| Solubility: | Soluble in 100% ethanol, acetone or ethyl acetate. |
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| Shipping: | Blue Ice |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Stable for at least 1 year after receipt when stored, as supplied, at -20°C. |
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| Handling: | Store at -20°C or colder. For experiments with cells or tissues, dissolve in ethanol and add aliquots directly to aqueous media. For HPLC, aliquots in acetone solution should be evaporated to dryness under a stream of nitrogen and HPLC mobile phase added to the desired concentration. Avoid basic conditions. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Down-regulation of cyclin D1 expression by prostaglandin A(2) is mediated by enhanced cyclin D1 mRNA turnover: S. Lin, et al.; Mol. Cell. Biol.
20, 7903 (2000),
Abstract;
Full Text
Interactions of prostaglandin A2 with the glutathione-mediated biotransformation system: M.L. van Iersel, et al.; Biochem. Pharmacol.
57, 1383 (1999),
Abstract;
p21Waf1 inhibits the activity of cyclin dependent kinase 2 by preventing its activating phosphorylation: M. Hitomi, et al.; Oncogene
17, 959 (1998),
Abstract;
Prostaglandin A2 blocks the activation of G1 phase cyclin-dependent kinase without altering mitogen-activated protein kinase stimulation: M. Hitomi, et al.; J. Biol. Chem.
271, 9376 (1996),
Abstract;
Full Text
Prostaglandin A2 and delta 12-prostaglandin J2 induce apoptosis in L1210 cells: I.K. Kim, et al.; FEBS Lett.
321, 209 (1993),
Abstract;
Growth inhibition of Friend erythroleukaemia cell tumours in vivo by a synthetic analogue of prostaglandin A: an action independent of natural killer-activity: S. Marini, et al.; Br. J. Cancer
61, 394 (1990),
Abstract;
Induction of gamma-glutamylcysteine synthetase by prostaglandin A2 in L-1210 cells: K. Ohno & M. Hirata; Biochem. Biophys. Res. Commun.
168, 551 (1990),
Abstract;
Prostaglandin J2--anti-tumour and anti-viral activities and the mechanisms involved: M. Fukushima; Eicosanoids
3, 189 (1990),
Abstract;
