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4α-Phorbol 12,13-didecanoate

TRPV4 agonist
 
BML-PE147-0001 1 mg 124.00 USD
 
BML-PE147-0005 5 mg 491.00 USD
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Replaces Prod. #: ALX-445-006

Negative control for phorbol 12,13-didecanoate. Activates TRPV4 (EC50 200-400nM)

Product Specification

Alternative Name:4αPDD
 
Formula:C40H64O8
 
MW:672.9
 
CAS:27536-56-7
 
Purity:≥99% (HPLC, TLC)
 
Appearance:Colorless film.
 
Solubility:Soluble in DMSO (25mg/ml), methanol, 100% ethanol, acetone, ether or dimethyl formamide.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Use/Stability:Stock solution cannot be made in aqueous media. Compound must be dissolved in an organic solvent prior to dilution into aqueous media. Add calculated volume of orgnic solvent to vial to prepare concentrated stock solution. Intermediate dilutions into the same organic solvent are recommended prior to final dilution into aqueous media. Store, as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months.
 
Handling:Protect from light.
 
445-006
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445-006

Product Literature References

Growth Hormone Releasing Peptide-2 Attenuation of Protein Kinase C-Induced Inflammation in Human Ovarian Granulosa Cells: Y.N. Chao, et al.; Int. J. Mol. Sci. 17, e1359 (2016), Application(s): Role of ghrelin in KGN human ovarian granulosa cells, Abstract; Full Text
The vallinoid transient receptor potential channel Trpv4: From structure to disease: W. Everaerts, et al.; Prog. Biophys. Mol. Biol. 103, 2 (2010), Abstract;
Functional Characterisation of Transient Receptor Potential Channels in Mouse Urothelial Cells: W. Everaerts, et al.; Am. J. Physiol. Renal Physiol. 298, F692 (2009), Abstract;
Modulation of the transient receptor potential vanilloid channel TRPV4 by 4alpha-phorbol esters: a structure-activity study: T.K. Klausen, et al.; J. Med. Chem. 52, 2933 (2009), Abstract; Full Text
TRPV4 calcium entry channel: a paradigm for gating diversity: B. Nilius, et al.; Am. J. Physiol. Cell Physiol. 286, C195 (2004), Abstract;
Activation of TRPV4 channels (hVRL-2/mTRP12) by phorbol derivatives: H. Watanabe, et al.; J. Biol. Chem. 277, 13569 (2002), Abstract;
Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters: M. Castagna, et al.; J. Biol. Chem. 257, 7847 (1982), Abstract;

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