Phorbol 12,13-didecanoate

PKC activator



BML-PE145-0001	1 mg	68.00 USD

BML-PE145-0005	5 mg	273.00 USD

Replaces Prod. #: ALX-445-002

Very potent and hydrophobic PKC activator(10-100ng/ml).

Product Specification

Formula:	C₄₀H₆₄O₈

MW:	672.9

Purity:	≥ 99%

Appearance:	Colorless oil.

Formulation:	Lyophilized

CAS:	24928-17-4

Solubility:	Soluble in DMSO or 100% ethanol.

Long Term Storage:	-20°C

Use/Stability:	Store, as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months.

Hazard:	HIGHLY IRRITANT. MAY BE CARCINOGENIC. VERY TOXIC.

Background / Technical Information:	Please click here for the comprehensive product datasheet.

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Product Literature References

Phorbol esters: structure, biological activity, and toxicity in animals: G. Goel, et al.; Int. J. Toxicol. 26, 279 (2007), Abstract;

Characterization of phorbol esters activity on individual mammalian protein kinase C isoforms, using the yeast phenotypic assay: L. Saraiva et al.; Eur. J. Pharmacol. 491, 101 (2004), Abstract;

Inhibition of queuine uptake in diploid human fibroblasts by phorbol-12,13-didecanoate. Requirement for a factor derived from early passage cells: M.S. Elliott & J.R. Katze; J. Biol. Chem. 261, 13019 (1986), Abstract;

Altered growth properties of normal human cells induced by phorbol 12,13-didecanoate: R.W. Trewyn & H.B. Gatz; In Vitro 20, 409 (1984), Abstract;

Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters: M Castagna et al.; J. Biol. Chem. 257, 7847 (1982), Abstract;