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Zardaverine

PDE inhibitor
 
BML-PD195-0005 5 mg 86.00 USD
 
BML-PD195-0025 25 mg 372.00 USD
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Selective, dual inhibitor of PDE III and PDE IV (IC50s=2.5 and 1.1 µM respectively). Anti-allergic activity, combined inhibition of PDE III and IV have an additive synergistic effect on inhibition of guinea pig bronchospasm.

Product Specification

Formula:C12H10F2N2O3
 
MW:268.2
 
CAS:101975-10-4
 
Purity:≥98% (HPLC)
 
Identity:Determined by 1H-NMR and MS.
 
Appearance:Off-white to yellow solid.
 
Solubility:Soluble in DMSO (25mg/ml).
 
Shipping:Ambient
 
Long Term Storage:Ambient
 
Use/Stability:Store solutions at -20°C for up to 3 months.
 
BML-PD195 structure
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BML-PD195 structure

Product Literature References

Comparison of phosphodiesterase III, IV and dual III/IV inhibitors on bronchospasm and pulmonary eosinophil influx in guinea pigs: D.C. Underwood, et al.; J. Pharmacol. Exp. Ther. 270, 250 (1994), Abstract;

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