Selective, dual inhibitor of PDE III and PDE IV (IC50s=2.5 and 1.1 µM respectively). Anti-allergic activity, combined inhibition of PDE III and IV have an additive synergistic effect on inhibition of guinea pig bronchospasm.
Product Details
| Formula: | C12H10F2N2O3 |
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| MW: | 268.2 |
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| CAS: | 101975-10-4 |
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| Purity: | ≥98% (HPLC) |
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| Identity: | Determined by 1H-NMR and MS. |
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| Appearance: | Off-white to yellow solid. |
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| Solubility: | Soluble in DMSO (25mg/ml). |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | +4°C |
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| Use/Stability: | Store solutions at -20°C for up to 3 months. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Comparison of phosphodiesterase III, IV and dual III/IV inhibitors on bronchospasm and pulmonary eosinophil influx in guinea pigs: D.C. Underwood, et al.; J. Pharmacol. Exp. Ther.
270, 250 (1994),
Abstract;
