Online Purchasing Account You are logged on as Guest. LoginRegister a New AccountShopping cart (Empty)
United States 

Trequinsin

PDE inhibitor
 
BML-PD180-0010 10 mg 279.00 USD
Do you need bulk/larger quantities?
 
Replaces Prod. #: ALX-270-126

Ultrapotent, highly selective inhibitor of cGMP-inhibited phosphodiesterase (PDE lll, IC50=0.3nM) in vitro. Potentiates adenosine-stimulated cAMP accumulation.

Product Specification

Alternative Name:9,10-Dimethoxy-2-mesitylimino-3-methyl-2,3,6,7-tetrahydro-4H-pyrimido-[6,1a]-isoquinolin-4-one . HCl, HL 725
 
Formula:C24H27N3O3 . HCl
 
MW:405.5 . 36.5
 
CAS:78416-81-6
 
Purity:≥98% (HPLC)
 
Identity:Determined by 1H-NMR and LC-MS.
 
Appearance:White to pale yellow solid.
 
Solubility:Soluble in DMSO (25mg/ml) or 100% ethanol (20mg/ml); slightly soluble in water.
 
Shipping:Ambient
 
Long Term Storage:Ambient
 
Use/Stability:Stable for at least 1 year after receipt when stored at +20°C. Solutions are stable for up to 3 months when stored at -20°C.
 
Handling:Protect from moisture.
 
Technical Info/Product Notes:Note: Product is not sterile.
 
bml-pd180
Please mouse over
bml-pd180

Product Literature References

Phosphodiesterase II, the cGMP-activatable cyclic nucleotide phosphodiesterase, regulates cyclic AMP metabolism in PC12 cells: M.E. Whalin, et al.; Mol. Pharmacol. 39, 711 (1991), Abstract;
Arachidonic acid metabolites, ADP and thrombin modulate occlusive thrombus formation over extensive arterial injury in the rat: F. DeClerck, et al.; Blood Coag. Fibrinol. 1, 247 (1990), Abstract;
Heparin-binding growth factor-1 modulation of plasminogen activator inhibitor-1 expression. Interaction with cAMP and protein kinase C- mediated pathways: B.A. Konkle, et al.; J. Biol. Chem. 265, 21867 (1990), Abstract; Full Text
HL 725, an extremely potent inhibitor of platelet phosphodiesterase and induced platelet aggregation in vitro: D. Rupert & K.U. Weithmann; Life Sci. 31, 2037 (1982), Abstract;

Product Toolbox

PRODUCT RESOURCES

Datasheet
MSDS
Certificate of Analysis

RELATED PRODUCTS

By target:
PDE
By biological activity:
PDE Inhibitor
By catalog section:

PRODUCT SUPPORT

FAQs
Technical Service
Customer Service

Recommend this page

 
For Research Use Only. Not for use in diagnostic procedures.
Keep in touch

©2017 Enzo Life Sciences, Inc.,