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Rolipram

PDE inhibitor
 
BML-PD175-0010 10 mg 68.00 USD
 
BML-PD175-0050 50 mg 290.00 USD
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Replaces Prod. #: ALX-270-119

Selective, cell permeable inhibitor of cAMP-specific phosphodiesterase (PDE IV, IC50=1 µM). A rolipram insensitive PDE IV subtype has been described.

Product Specification

Alternative Name:(±)-4-[3-(Cyclopentyloxy)-4-methoxyphenyl]-2-pyrrolidinone
 
Formula:C16H21NO3
 
MW:275.4
 
CAS:61413-54-5
 
MI:14: 8251
 
RTECS:UY5749237
 
Purity:≥98% (TLC)
 
Appearance:White to off-white solid.
 
Solubility:Soluble in DMSO (25mg/ml, warm), 100% ethanol (25mg/ml, warm) or acetone.
 
Shipping:Ambient
 
Long Term Storage:Ambient
 
Use/Stability:Stable for at least 5 year after receipt when stored at +20°C. Stock solutions are stable for up to 3 months at -20°C.
 
Technical Info/Product Notes:Note: Product is not sterile.
 
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Product Literature References

Cyclic AMP Mimics the Anti-ageing Effects of Calorie Restriction by Up-Regulating Sirtuin: Z. Wang, et al.; Sci. Rep. 5, 12012 (2015), Application(s): Cell Culture, Abstract; Full Text
Persistent signaling induced by FTY720-phosphate is mediated by internalized S1P1 receptors: F. Mullershausen, et al.; Nat. Chem. Biol. 5, 428 (2009), Abstract;
Comparison of phosphodiesterase III, IV and dual III/IV inhibitors on bronchospasm and pulmonary eosinophil influx in guinea pigs: D.C. Underwood, et al.; J. Pharmacol. Exp. Ther. 270, 250 (1994), Abstract;
Bemoradan--a novel inhibitor of the rolipram-insensitive cyclic AMP phosphodiesterase from canine heart tissue: J.B. Moore, et al.; Biochem. Pharmacol. 42, 679 (1991), Abstract;
The identification of a new cyclic nucleotide phosphodiesterase activity in human and guinea-pig cardiac ventricle. Implications for the mechanism of action of selective phosphodiesterase inhibitors: M.L. Reeves, et al.; Biochem. J. 241, 535 (1987), Abstract;
Stereospecific binding of the antidepressant rolipram to brain protein structures: H.H. Schneider, et al.; Eur. J. Pharmacol. 127, 105 (1986), Abstract;

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