Cilostamide

PDE inhibitor



BML-PD125-0005	5 mg	59.00 USD

BML-PD125-0025	25 mg	239.00 USD

Replaces Prod. #: ALX-270-404

Phosphodiesterase PDE3 inhibitor (IC₅₀=5 nM). Blocks PKB/Akt signaling pathway by inhibition of Akt-activated PDE3B. Reverses the established effects of leptin on food intake and body weight. Blocks the leptin-induced tyrosine phosphorylation of STAT3 at the hypothalamic level.

Product Specification

Alternative Name:	OCP 3689, OPS 3689, N-Cyclohexyl-N-methyl-4-(1,2-dihydro-2-oxo-6-quinolyloxy)butyramide

Formula:	C₂₀H₂₆N₂O₃

MW:	342.2

Purity:	≥98% (TLC)

Appearance:	White solid.

CAS:	68550-75-4

Solubility:	Soluble in DMSO (25mg/ml).

Long Term Storage:	Ambient

Use/Stability:	Stable for at least 1 year after receipt when stored, as supplied, at room temperature. Stock solutions are stable for up to 3 months at -20°C.

Handling:	Packaged under inert gas. Protect from light and oxygen.

Background / Technical Information:	Please click here for the comprehensive product datasheet.

Product Literature References

Local and long-range reciprocal regulation of cAMP and cGMP in axon/dendrite formation: M. Shelly, et al.; Science 327, 547 (2010), Abstract;

A phosphatidylinositol 3-kinase phosphodiesterase 3B-cyclic AMP pathway in hypothalamic action of leptin on feeding: A.Z. Zhao, et al.; Nat. Neurosci. 5, 727 (2002), Abstract;

Cyclic nucleotide phosphodiesterase 3B is a downstream target of protein kinase B and may be involved in regulation of effects of protein kinase B on thymidine incorporation in FDCP2 cells: F. Ahmad, et al.; J. Immunol. 164, 4678 (2000), Abstract;

Protein kinase B/Akt induces resumption of meiosis in Xenopus oocytes: C.B. Andersen, et al.; J. Biol. Chem. 273, 18705 (1998), Abstract;

Selective inhibitors of three forms of cyclic nucleotide phosphodiesterase--basic and potential clinical applications: H. Hidaka & T. Endo; Adv. Cyclic Nucleotide Protein Phosphorylation Res. 16, 245 (1984), Abstract;