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Cilostamide

PDE inhibitor
 
BML-PD125-0005 5 mg 68.00 USD
 
BML-PD125-0025 25 mg 279.00 USD
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Replaces Prod. #: ALX-270-404

Phosphodiesterase PDE3 inhibitor (IC50=5 nM). Blocks PKB/Akt signaling pathway by inhibition of Akt-activated PDE3B. Reverses the established effects of leptin on food intake and body weight. Blocks the leptin-induced tyrosine phosphorylation of STAT3 at the hypothalamic level.

Product Specification

Alternative Name:OCP 3689, OPS 3689, N-Cyclohexyl-N-methyl-4-(1,2-dihydro-2-oxo-6-quinolyloxy)butyramide
 
Formula:C20H26N2O3
 
MW:342.4
 
CAS:68550-75-4
 
Purity:≥98% (TLC)
 
Identity:Determined by NMR.
 
Appearance:White to off-white solid.
 
Solubility:Soluble in DMSO (25mg/ml).
 
Shipping:Ambient
 
Long Term Storage:Ambient
 
Use/Stability:Stable for at least 1 year after receipt when stored, as supplied, at room temperature. Stock solutions are stable for up to 3 months at -20°C.
 
Handling:Protect from light and oxygen. Packaged under inert gas.
 
BML-PD125 structure
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BML-PD125 structure

Product Literature References

Cilostamide and forskolin treatment during pre-IVM improves preimplantation development of cloned embryos by influencing meiotic progression and gap junction communication in pigs: B. Park, et al.; Theriogenology 86, 757 (2016), Abstract;
Immature Oocytes from Unprimed Juvenile Mice Become a Valuable Source for Embryo Production When Using C-Type Natriuretic Peptide as Essential Component of Culture Medium: S. Romero, et al.; Biol. Reprod. 95, 64 (2016), Application(s): Comparative developmental capacity of oocytes undergoing Pre-IVM in presence of CNP or an inhibitor of phosphodiesterase type 3 (PDE3-I), Abstract; Full Text
Local and long-range reciprocal regulation of cAMP and cGMP in axon/dendrite formation: M. Shelly, et al.; Science 327, 547 (2010), Abstract;
A phosphatidylinositol 3-kinase phosphodiesterase 3B-cyclic AMP pathway in hypothalamic action of leptin on feeding: A.Z. Zhao, et al.; Nat. Neurosci. 5, 727 (2002), Abstract;
Cyclic nucleotide phosphodiesterase 3B is a downstream target of protein kinase B and may be involved in regulation of effects of protein kinase B on thymidine incorporation in FDCP2 cells: F. Ahmad, et al.; J. Immunol. 164, 4678 (2000), Abstract;
Protein kinase B/Akt induces resumption of meiosis in Xenopus oocytes: C.B. Andersen, et al.; J. Biol. Chem. 273, 18705 (1998), Abstract;
Selective inhibitors of three forms of cyclic nucleotide phosphodiesterase--basic and potential clinical applications: H. Hidaka & T. Endo; Adv. Cyclic Nucleotide Protein Phosphorylation Res. 16, 245 (1984), Abstract;

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For Research Use Only. Not for use in diagnostic procedures.
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