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RGD peptide

Integrin ligand
 
BML-P700-0005 5 mg 135.00 USD
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Induces apoptosis in various cell types and cell lines at 1mM by a mechanism involving cellular uptake and possible direct stimulation of procaspase-3 autoprocessing. Does not induce apoptosis in the breast cancer line MCF-7, in which there is a functional deletion of the procaspase-3 gene. Contains the motif RGD (Arg-Gly-Asp) which is found in many integrin ligands. Inhibits cell adhesion of COS-7 cells to fibronectin 80-90% at 1mM.

Product Specification

Alternative Name:GRGDNP
 
Sequence:Gly-Arg-Gly-Asp-Asn-Pro
 
MW:614.6
 
CAS:114681-65-1
 
Formulation:Lyophilized.
 
Purity:≥97% (HPLC)
 
Appearance:Solid.
 
Solubility:Soluble in water (>50mg/ml).
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 

Product Literature References

Cortical actin regulation modulates vascular contractility and compliance in veins: R.J. Saphirstein, et al.; J. Physiol. 593, 3929 (2015), Application(s): Coupling to magnetic beads, Abstract; Full Text
β1 integrins mediate attachment of mesenchymal stem cells to cartilage lesions: D. Zwolanek, et al.; Biores. Open Access 4, 39 (2015), Application(s): Cell treatment, Abstract; Full Text
Vascular endothelial cells promote cortical neurite outgrowth via an integrin β3-dependent mechanism: S. Sumimoto, et al.; Biochem. Biophys. Res. Commun. 450, 593 (2014), Application(s): Cell treatment, Abstract;
Kindlin-1 regulates mitotic spindle formation by interacting with integrins and Plk-1: H. Patel, et al.; Nat. Commun. 4, 2056 (2013), Application(s): Cell treatment, Abstract;
The focal adhesion: a regulated component of aortic stiffness: R.J. Saphirstein, et al.; PLoS One 8, e62461 (2013), Application(s): Coupling to magnetic beads, Abstract;
Endothelial-derived thrombospondin-1 promotes macrophage recruitment and apoptotic cell clearance: T. Kirsch, et al.; J. Cell. Mol. Med. 14, 1922 (2010), Application(s): Cell treatment, Abstract; Full Text
Activation of the Cdc42-associated tyrosine kinase-2 (ACK-2) by cell adhesion via integrin beta1: W. Yang et al.; J. Biol. Chem. 274, 8524 (1999), Abstract;
RGD peptides induce apoptosis by direct caspase-3 activation: C. D. Buckley et al.; Nature 397, 534 (1999), Abstract;
ECM and cell surface proteolysis: regulating cellular ecology: Z. Werb et al.; Cell 91, 439 (1997), Abstract;
Integrins, adhesion and apoptosis: J. E. Meredith et al.; Trends Cell Biol. 7, 146 (1997), Abstract;
RGD and other recognition sequences for integrins: E. Ruoslahti et al.; Annu. Rev. Cell. Dev. Biol. 12, 697 (1996), Abstract;

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