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IKK-NBD peptide

NF-κB inhibitor
BML-P607-0500 0.5 mg 176.00 USD
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The peptide consists of two domains - an antennapedia homeodomain that confers cell permeability and the T735 to E745 region of IKKβ which is the NEMO binding domain (NBD). It is a selective inhibitor of NFκB activation. Blocks interaction of NEMO (an IKB complex regulatory protein) with the IκB kinase complex. The peptide (100 µM) inhibits E-selectin expression in human umbilical vein endothelial cells treated with TNFα and inhibits LPS-induced nitric acid release from a macrophage cell line In an experimental mouse model of acute inflammation, IKK-NBD peptide (topically applied) inhibited PMA induced ear inflammation. Sold under license from Vanderbilt University

Product Specification

Purity:≥95% (HPLC)
Appearance:Lyophilized solid
Solubility:Soluble in DMSO (20mM). Note: This peptide will precipitate when added to tissue culture medium, even to 100µM. However, enough will remain in solution to enter many cell types.
Shipping:Shipped on Blue Ice
Long Term Storage:-20°C

Product Literature References

Ethanol Decreases Inflammatory Response in Human Lung Epithelial Cells by Inhibiting the Canonical NF-kB-Pathway: K. Mors, et al.; Cell. Physiol. Biochem. 43, 17 (2017), Abstract; Full Text
Selective inhibition of NF-kappaB activation by a peptide that blocks the interaction of NEMO with the IkappaB kinase complex: M. J. May et al.; Science 289, 5484 (2000), Abstract;
Identification of Grb2 as a novel binding partner of tumor necrosis factor (TNF) receptor I: E. Hildt et al.; J. Exp. Med. 189, 1707 (1999), Abstract;
Complementation cloning of NEMO, a component of the IkappaB kinase complex essential for NF-kappaB activation: S. Yamaoka et al.; Cell 93, 1231 (1998), Abstract;

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