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NF-κB SN50M cell permeable control peptide

Negative control for NF-κB SN50
 
BML-P601-0500 0.5 mg 123.00 USD
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Replaces Prod. #: ALX-167-025

Inactive control peptide for the cell-permeable NF-κB inhibitory peptide SN50. Contains the nuclear localization sequence (NLS residues 360-369) of the transcription factor NF-κB p50 linked to the hydrophobic region (h-region) of the signal peptide of Kaposi fibroblast growth factor (K-FGF), except this control peptide has Lys363 to Asn and Arg364 to Gly. In mouse endothelial LE-II cells induced with LPS, SN50M peptide had no measureable effect on NF-κB translocation at 50 µg/ml. In human monocytic THP-1 cells induced by LPS or TNFα, there was slight inhibition of nuclear transport at 100 µg/ml. Sold under license from Vanderbilt University.

Product Specification

Sequence:H-Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Pro-Val-Gln-Arg-Asn-Gly-Gln-Lys-Leu-Met-Pro-OH
 
Formula:C123H215N33O30S
 
MW:2668.0
 
Formulation:Lyophilized. Counter Ion: Trifluoroacetate salt.
 
Purity:≥97% (HPLC)
 
Appearance:White to off-white solid.
 
Solubility:Soluble in water.
 
Reconstitution:Reconstitute in sterile, distilled water.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Use/Stability:Peptides in solution have limited stability.
 
Handling:Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20°C.
 

Product Literature References

Transcriptional Regulation of the Sodium-activated Potassium Channel SLICK (KCNT2) promoter by nuclear factor-kappa B: D.L. Tomasello, et al.; J. Biol. Chem. 290, 18575 (2015), Application(s): Cell Culture, Abstract; Full Text
GDP-mannose-4,6-dehydratase (GMDS) deficiency renders colon cancer cells resistant to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) receptor- and CD95-mediated apoptosis by inhibiting complex II formation: K. Moriwaki, et al.; J. Biol. Chem. 286, 43123 (2011), Abstract; Full Text
Interruption of the NF-kappaB pathway by Bay 11-7082 promotes UCN-01-mediated mitochondrial dysfunction and apoptosis in human multiple myeloma cells.: Y. Dai et al.; Blood 103, 2761 (2004), Abstract; Full Text
Inhibition of nuclear translocation of transcription factor NF-kappa B by a synthetic peptide containing a cell membrane-permeable motif and nuclear localization sequence.: Y. Z. Lin et al.; J. Biol. Chem. 270, 14255 (1995), Abstract;

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For Research Use Only. Not for use in diagnostic procedures.
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