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NF-κB SN50 cell permeable inhibitory peptide

Inhibits NF-κB translocation
 
BML-P600-0005 0.5 mg 138.00 USD
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Sequence contains the nuclear localization sequence (NLS residues 360-369) of the transcription factor NF-κB p50 linked to a peptide cell-permeablization sequence, the hydrophobic region (h-region) of the signal peptide of Kaposi fibroblast growth factor (K-FGF). Peptide inhibits translocation of the NF-κB active complex into the nucleus. In mouse endothelial LE-II cells induced with LPS, inhibition of NF-κB nuclear translocation was 88% at 50µg/ml (18 µM). In human monocytic THP-1 cells induced by LPS or TNFα there was 85% inhibition at 100µg/ml. Sold under license from Vanderbilt University.

Product Specification

Sequence:Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Pro-Val-Gln-Arg-Lys-Arg-Gln-Lys-Leu-Met-Pro
 
MW:2781.5
 
CAS:213546-53-3
 
Purity:≥97% (HPLC)
 
Appearance:Lyophilized solid.
 
Solubility:Soluble in water, 100% ethanol or 50% ethanol.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 

Product Literature References

Cigarette smoke extract (CSE) induces transient receptor potential ankyrin 1 (TRPA1) expression via activation of HIF1α in A549 cells: Y. Nie, et al.; Free Radic. Biol. Med. 99, 498 (2016), Application(s): Cell culture, NF-κ B inhibiton, Abstract;
Functional Roles of NOD1 in Odontoblasts on Dental Pulp Innate Immunity: Y. Hosokawa, et al.; Biomed. Res. Int. 2016, 9325436 (2016), Application(s): Cell Signaling Pathways in iE-DAP- or TNF-a-Stimulated KN-3 Cells, Abstract; Full Text
Platelet-activating factor and hydrogen peroxide exert a dual modulatory effect on the transcription of LXRα and its target genes in human neutrophils: M. Reyes-Quiroz, et al.; Int. Immunopharmacol. 38, 357 (2016), Application(s): Incubation with neutrophils to study platelet-activating factor effects in inflammation, Abstract;
TLR4-Upregulated IL-1β and IL-1RI Promote Alveolar Macrophage Pyroptosis and Lung Inflammation through an Autocrine Mechanism: X. He, et al.; Sci. Rep. 6, 31663 (2016), Application(s): Determination of the receptor signaling pathway that mediates IL-1RI up-regulation, Abstract; Full Text
GDP-mannose-4,6-dehydratase (GMDS) deficiency renders colon cancer cells resistant to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) receptor- and CD95-mediated apoptosis by inhibiting complex II formation: K. Moriwaki, et al.; J. Biol. Chem. 286, 43123 (2011), Abstract; Full Text
Thyroid-stimulating hormone induces interleukin-6 release from human adipocytes through activation of the nuclear factor-kappaB pathway: T.T. Antunes, et al.; Endocrinology 149, 3062 (2008), Application(s): ELISA using culture supernatants, Abstract;
Inhibition of nuclear translocation of transcription factor NF-kappa B by a synthetic peptide containing a cell membrane-permeable motif and nuclear localization sequence: J.-Z. Lin et al.; J. Biol. Chem. 270, 14255 (1995), Abstract;

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