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Ac-VEID-pNA

Caspase substrate
 
BML-P437-0005 5 mg 118.00 USD
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Replaces Prod. #: ALX-260-063

Colorimetric substrate for caspase-6 (Km=30µM; Kcat/Km=168’000 M-1sec-1) and related cysteine proteases. Sequence is based on the lamin A site of cleavage. Cleavage of the substrate by a caspase releases pNA, which can be detected by its absorbance at 405nm (ε=10,500 M-1cm-1).

Product Specification

Alternative Name:Caspase-6 substrate (chromogenic)
 
Identity:Determined by MS.
 
Sequence:N-acetyl-Val-Glu-Ile-Asp-pNA (p-nitroanilide)
 
MW:637.5
 
Source:Synthetic.
 
Formulation:Lyophilized.
 
Purity:≥95% (HPLC)
 
Appearance:White to off-white powder.
 
Solubility:Soluble in water.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Use/Stability:Store stock solution in water (e.g. 50mM) at -20°C.
 

General Literature References

A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis.: N.A. Thornberry et al.; J. Biol. Chem. 272, 17907 (1997), Abstract;
Substrate specificities of caspase family proteases.: R.V. Talanian et al.; J. Biol. Chem. 272, 9677 (1997), Abstract;
The Ced-3/interleukin 1beta converting enzyme-like homolog Mch6 and the lamin-cleaving enzyme Mch2alpha are substrates for the apoptotic mediator CPP32.: S.M. Srinivasula et al.; J. Biol. Chem. 271, 27099 (1996), Abstract;

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