Online Purchasing Account You are logged on as Guest. LoginRegister a New AccountShopping cart (Empty)
United States 

Ac-AAVALLPAVLLALLAPYVAD-CHO

Caspase inhibitor
 
BML-P404-0005 0.5 mg 128.00 USD
Do you need bulk/larger quantities?
 
The YVAD-CHO portion of this peptide is a highly-specific, potent (Ki=1 nM) and reversible inhibitor of caspase-1 (interleukin-1β converting enzyme, ICE), whose sequence is based on the pre-interleukin-1β Asp-116 cleavage site for caspase-1. The sequence linked N-terminal to YVAD-CHO (residues 1-16) has been shown to enhance cell permeability, as described for ALX-260-046. The efficacy of the resulting chimeric peptide, for caspase-1 inhibition, is unknown.

Product Specification

Alternative Name:Caspase-1 inhibitor (aldehyde)
 
Sequence:N-acetyl-Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Pro-)Tyr-Val-Ala-Asp-CHO(aldehyde)
 
MW:1990.4
 
Formulation:Lyophilized.
 
Purity:≥95%
 
Application Notes:Preincubate cultured cells 1-2 hrs. with 0.1-2.0 µM of the peptide, before inducing for apoptosis. Measure indicator(s) of apoptosis at a number of time points, since the effect of the inhibitor may be a delay in the onset of apoptosis, rather than permanent inhibition. It may also be helpful to determine a minimum effective concentration for the apoptosis inducer and use that concentration, when attempting to observe the effects of this peptide. 
 
Reconstitution:Reconstitute with water (add a small amount of ammonium hydroxide or NaOH to solubilize).
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 

Product Literature References

Inhibition of caspase-1 induces cell death in pancreatic carcinoma cells and potentially modulates expression levels of bcl-2 family proteins: S. Schlosser, et al.; FEBS Lett. 23, 104 (2001), Abstract;

Product Toolbox

PRODUCT RESOURCES

Datasheet
MSDS
Certificate of Analysis

RELATED PRODUCTS

By target:
Caspase
Caspase-1
By biological activity:
Caspase Inhibitor
Caspase-1 Inhibitor
By catalog section:

PRODUCT SUPPORT

FAQs
Technical Service
Customer Service

Recommend this page

 
For Research Use Only. Not for use in diagnostic procedures.
Keep in touch

©2017 Enzo Life Sciences, Inc.,