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IRS-1 (Tyr608) peptide

Insulin receptor substrate
 
BML-P320-0001 1 mg 131.00 USD
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This sequence, KKHTDDGYMPMSPGVA, is from insulin receptor substrate-1 (IRS-1) inclusive of Tyr608 (mouse) -Tyr612 (human). It contains the insulin receptor tyrosine kinase substrate motif YMXM (Tyr-Met-X-Met). This peptide has been used as a substrate for purified insulin receptor (Km=90 µM) and other tyrosine kinases in phosphocellulose binding assays. The tyrosine phosphorylated version of this peptide binds to phosphatidylinositol 3-kinase (PI 3-kinase) SH2 domain and activates the enzyme.

Product Specification

Alternative Name:Insulin receptor substrate (Tyr608) peptide
 
Sequence:Lys-Lys-His-Thr-Asp-Asp-Gly-Tyr-Met-Pro-Met-Ser-Pro-Gly-Val-Ala
 
MW:1732.8
 
Source:Synthetic.
 
Formulation:Lyophilized.
 
Purity:≥95% (HPLC)
 
Appearance:White to off-white powder.
 
Solubility:Soluble in water.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 

Product Literature References

Regulation of phosphatidylinositol 3'-kinase by tyrosyl phosphoproteins. Full activation requires occupancy of both SH2 domains in the 85-kDa regulatory subunit: T. Rordorf-Nikolic, et al.; J. Biol. Chem. 270, 3662 (1995), Abstract;
Phosphorylation of synthetic peptides containing Tyr-Met-X-Met motifs by nonreceptor tyrosine kinases in vitro: P. Garcia, et al.; J. Biol. Chem. 268, 25146 (1993), Abstract;
YMXM motifs of IRS-1 define substrate specificity of the insulin receptor kinase: S.E. Shoelson, et al.; Proc. Natl. Acad. Sci. USA 89, 2027 (1992), Abstract; Full Text

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