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TACE substrate II (fluorogenic)

 
BML-P228-0100 100 µg 123.00 USD
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Sensitive fluorogenic substrate for TACE (TNFα converting enzyme, ADAM17). Also cleaved by ADAM10 and likely other ADAMs and MMPs. The kcat/Km of TACE for this substrate is 7-fold higher than for the same peptide with the Mca-Dpa fluorophore-quencher pair. FAM fluorescence is quenched by the TAMRA group until cleavage separates them. Ex.: 485nm, Em.: 535nm, although the following Ex/Em can also be used: 490,494/515,520nm. This substrate is useful for inhibitor screening, kinetic analysis, and cellular activity assay.

Product Specification

Alternative Name:ADAM17 substrate II (fluorogenic)
 
Sequence:5-FAM-Ser-Pro-Leu-Ala-Gln-Ala-Val-Arg-Ser-Ser-Ser-Arg-Lys(5-TAMRA)-NH2
 
MW:2157.3
 
Formulation:Lyophilized.
 
Purity:≥95% (HPLC)
 
Appearance:Solid.
 
Solubility:Soluble in DMSO.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Handling:Protect from light and moisture.
 

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