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AIP (myristoylated)

CaM kinase inhibitor
 
BML-P212-0500 0.5 mg 116.00 USD
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Product Specification

Alternative Name:Autocamtide-2-related inhibitory peptide (myristoylated)
 
Identity:Determined by MS.
 
Sequence:N-Myr-Lys-Lys-Ala-Leu-Arg-Arg-Gln-Glu-Ala-Val-Asp-Ala-Leu
 
MW:1707.9
 
Source:Synthetic.
 
Formulation:Lyophilized. Trifluoroacetate salt.
 
Purity:≥95% (HPLC)
 
Appearance:Powder.
 
Solubility:Soluble in 30% Acetic Acid in Water (5 mg/ml).
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Handling:Protect from moisture.
 
Technical Info/Product Notes:AIP (autocamtide-2-related inhibitory peptide, Prod. No. BML-P211) is a highly-specific and potent inhibitor of CaM kinase II. The sequence is derived from autocamtide-2 (Prod. No. BML-P101) but alanine is substituted for threonine at the 9-position.  AIP at 1 µM completely inhibited CaM kinase II but did not affect PKC, PKA, CaMKIV and other brain extract kinases. Myristoylated AIP (Prod. No. BML-P212) is the same sequence as AIP but is N-terminal myristoylated to increase cell-permeability.
 

Product Literature References

CaMKII regulates proteasome phosphorylation and activity and promotes memory destabilization following retrieval: T.J. Jarome, et al.; Neurobiol. Learn. Mem. 128, 103 (2016), Application(s): Cell culture, Abstract;

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