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PKI (5-24)

PKA inhibitor
 
BML-P203-0500 0.5 mg 116.00 USD
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Replaces Prod. #: ALX-151-014

Sequence is from the heat-stable skeletal muscle inhibitor protein of PKA. Peptide binds to the catalytic subunit of PKA and displaces the regulatory subunit. Mimics protein substrate by binding to the catalytic site via the Arg-cluster basic residues. Ki =2.3 nM for PKA.

Product Specification

Alternative Name:cAMP-dependent protein kinase inhibitor (5-24)
 
Sequence:Thr-Thr-Tyr-Ala-Asp-Phe-Ile-Ala-Ser-Gly-Arg-Thr-Gly-Arg-Arg-Asn-Ala-Ile-His-Asp
 
Formula:C94H148N32O31 
 
MW:2222.7
 
Source:Synthetic.
 
CAS:99534-03-9
 
Formulation:Lyophilized.
 
Purity:≥95% (HPLC)
 
Appearance:White to off-white solid
 
Solubility:Soluble in water.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Use/Stability:Store, as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months.
 

Product Literature References

Structure of a peptide inhibitor bound to the catalytic subunit of cyclic adenosine monophosphate-dependent protein kinase: D. R. Knighton et al.; Science 253, 414 (1991), Abstract;
A potent synthetic peptide inhibitor of the cAMP-dependent protein kinase: H. C. Cheng et al.; J. Biol. Chem. 261, 989 (1986), Abstract;

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