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Z-AAD-CMK

Caspase inhibitor
 
BML-P165-0001 1 mg 138.00 USD
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Irreversible, cell-permeable inhibitor of granzyme B (ID50=0.3 µM). Does not inhibit granzyme A. Inhibition of granzyme B with Z-AAD-CMK prevented caspase-3 activation in T cells.

Product Specification

Alternative Name:Granzyme B inhibitor
 
Identity:Determined by MS.
 
Sequence:Benzyloxycarbonyl-Ala-Ala-Asp-chloromethylketone
 
Formula:C19H24ClN3O7
 
MW:442.4
 
Source:Synthetic.
 
Formulation:Lyophilized.
 
Purity:≥95% (HPLC)
 
Appearance:White to off-white solid.
 
Solubility:Soluble in DMSO (25mg/ml), 100% ethanol (25mg/ml) or water (20mg/ml).
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Use/Stability:Store, as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months.
 
Handling:After reconstitution, prepare aliquots and store at -20°C.
 

Product Literature References

Granzyme B expression is enhanced in human monocytes by TLR8 agonists and contributes to antibody-dependent cellular cytotoxicity: S. Elavazhagan, et al.; J. Immunol. 194, 2786 (2015), Abstract; Full Text
Cytotoxic T cells induce proliferation of chronic myeloid leukemia stem cells by secreting interferon-γ: C. Schürch, et al.; J. Exp. Med. 210, 605 (2013), Abstract; Full Text
IFN-γ stimulated human umbilical-tissue-derived cells potently suppress NK activation and resist NK-mediated cytotoxicity in vitro: C. Noone, et al.; Stem Cells Dev. 22, 3003 (2013), Abstract; Full Text
IL-21–stimulated human plasmacytoid dendritic cells secrete granzyme B, which impairs their capacity to induce T-cell proliferation: J.J. Karrich, et al.; Blood. 121, 3103 (2013), Abstract; Full Text
Tumor-reactive CD4+ T cells develop cytotoxic activity and eradicate large established melanoma after transfer into lymphopenic hosts: S.A. Quezada, et al.; J. Exp. Med. 207, 637 (2010), Abstract; Full Text

General Literature References

Selective inhibition of dipeptidyl peptidase I, not caspases, prevents the partial processing of procaspase-3 in CD3-activated human CD8(+) T lymphocytes.: N. Bidere et al.; J. Biol. Chem. 277, 32339 (2002), Abstract;
Granzymes (lymphocyte serine proteases): characterization with natural and synthetic substrates and inhibitors.: C.M. Kam et al.; Biochem. Biophys. Acta 1477, 301 (2000), Abstract;

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