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Abz-FRK(Dnp)-P

ACE substrate
 
BML-P161-0001 1 mg 116.00 USD
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Fluorogenic substrate for angiotensin converting enzyme-1 (ACE1). The somatic form of ACE1 is a zinc-dependent peptidyl dipeptidase comprising two catalytic domains referred to as the N- and C-domains. The testicular form, due to a downstream start site, contains only the C-domain. Abz fluorescence is quenched by the Dnp group until cleavage (at Arg-Lys) separates them. Ex: 320 nm, Em: 420 nm. This quenched substrate is useful for assay of plasma, tissue, and cell culture ACE1 activity, inhibitor screening and kinetic analysis.

Product Specification

Alternative Name:ACE1 substrate (fluorogenic)
 
Sequence:Abz-Phe-Arg-Lys(Dnp)-Pro-OH[Abz=o-aminobenzoicacid;Dnp=2,4-dinitrophenyl]
 
MW:831.4
 
CAS:500799-61-1
 
Purity:≥95%
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 

Product Literature References

Chymase-dependent production of angiotensin II: an old enzyme in old hearts: G. Froogh, et al.; Am. J. Physiol. Heart Circ. Physiol. 312, H223 (2017), Abstract;

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Angiotensin converting enzyme
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For Research Use Only. Not for use in diagnostic procedures.
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