This peptide sequence, RRRAAEELDSRAGpSPQL, corresponds to the sequence of the ε subunit of elF2B surrounding Ser540, a target of GSK-3 (glycogen synthase kinase 3) phosphorylation, with the addition of a phosphoserine in the 4 position. This phosphoserine allows for more efficient phosphorylation of the second serine in the peptide(Km=49 µM for GSK-3ß, 83 µM for GSK-3α). Useful in phosphocellulose GSK-3α and -ß assays.
Product Details
| Alternative Name: | Glycogen synthase kinase 3 substrate |
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| Sequence: | H-Arg-Arg-Arg-Ala-Ala-Glu-Glu-Leu-Asp-Ser-Arg-Ala-Gly-pSer-Pro-Gln-Leu-OH |
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| MW: | 1992.0 |
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| Shipping: | Blue Ice Not Frozen |
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| Long Term Storage: | -20°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
A genetic model to study O-GlcNAc cycling in immortalized mouse embryonic fibroblasts: M.M. St Amand, et al.; J. Biol. Chem.
293, 13673 (2018),
Abstract;
Upregulation of calpain activity precedes tau phosphorylation and loss of synaptic proteins in Alzheimer’s disease brain: K. Kurbatskaya, et al.; Acta. Neuropathol. Commun.
4, 34 (2016),
Application(s): Western blot,
Abstract;
Full Text
Selectivity and anti-Parkinson's potential of thiadiazolidinone RGS4 inhibitors: L.L. Blazer, et al.; ACS Chem. Neurosci.
6, 911 (2015),
Abstract;
