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GSK3 substrate

 
BML-P151-0001 1 mg 128.00 USD
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This peptide sequence, RRRAAEELDSRAGpSPQL, corresponds to the sequence of the ε subunit of elF2B surrounding Ser540, a target of GSK-3 (glycogen synthase kinase 3) phosphorylation, with the addition of a phosphoserine in the 4 position. This phosphoserine allows for more efficient phosphorylation of the second serine in the peptide(Km=49 µM for GSK-3ß, 83 µM for GSK-3α). Useful in phosphocellulose GSK-3α and -ß assays.

Product Specification

Alternative Name:Glycogen synthase kinase 3 substrate
 
Sequence:H-Arg-Arg-Arg-Ala-Ala-Glu-Glu-Leu-Asp-Ser-Arg-Ala-Gly-pSer-Pro-Gln-Leu-OH
 
MW:1992.0
 
Shipping:Blue Ice Not Frozen
 
Long Term Storage:-20°C
 

Product Literature References

Upregulation of calpain activity precedes tau phosphorylation and loss of synaptic proteins in Alzheimer’s disease brain: K. Kurbatskaya, et al.; Acta. Neuropathol. Commun. 4, 34 (2016), Application(s): Western blot, Abstract; Full Text

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For Research Use Only. Not for use in diagnostic procedures.
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