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Cathepsin K substrate
BML-P142-0005 5 mg 101.00 USD
BML-P142-0020 20 mg 295.00 USD
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Fluorogenic substrate specific for cathepsin K, among other cathepsin family members. This substrate is also cleaved by granzyme A, thrombin, tryptase, trypsin, and kallikreins. Ex.: 365 nm, Em.: 440 nm, although the following Ex/Em can also be used: 355,380/450,460. This substrate is useful for inhibitor screening and kinetic analysis. Also available: fluorogenic calibration standard AMC (BML-KI144).

Product Specification

Alternative Name:Z-Gly-Pro-Arg-AMC
Sequence:Z-Gly-Pro-Arg-AMC . HCl [Z=Cbz=Benzyloxycarbonyl; AMC=7-amino-4-methylcoumarin]
Purity:≥97% (HPLC)
Appearance:White powder.
Shipping:Shipped on Blue Ice
Long Term Storage:-20°C

Product Literature References

Development of a highly potent, selective, and cell-active Inhibitor of cysteine cathepsin L-A hybrid design approach: D. Dana, et al.; Chem. Commun. (Camb.) 50, 10875 (2014), Abstract;

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For Research Use Only. Not for use in diagnostic procedures.
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