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Ac-IEPD-AMC

Caspase substrate
 
BML-P134-0005 5 mg 170.00 USD
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Replaces Prod. #: ALX-260-151

Fluorogenic substrate for caspase-8 and granzyme B. Ex.: 360 nm, Em.: 450 nm. The Km of recombinant human granzyme B for Ac-IEPD-AMC is 160 µM, with a Vmax about eight-fold lower than that of Ac-IEPD-pNA (BML-P133).

Product Specification

Alternative Name:Caspase-8 substrate (fluorogenic), Granzyme B substrate (fluorogenic)
 
Sequence:N-acetyl-Ile-Glu-Pro-Asp-AMC (7-amino-4-methylcoumarin)
 
Formula:C32H41N5O11
 
MW:671.8
 
Purity:≥95%
 
Appearance:White to off-white powder.
 
Solubility:Soluble in DMSO.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Use/Stability:Stock solution in DMSO (e.g. 0.1M) is highly stable at -20°C or -70°C.
 
Handling:Keep cool and dry.
 

Product Literature References

Definition and redesign of the extended substrate specificity of granzyme B: J.L. Harris, et al.; J. Biol. Chem. 273, 27364 (1998), Abstract;
A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis: N.A. Thornberry, et al.; J. Biol. Chem. 272, 17907 (1997), Abstract;

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