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TACE substrate (fluorogenic)

 
BML-P132-0500 0.5 mg 128.00 USD
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Item sold as 0.5mg net peptide.

Fluorogenic substrate for TACE (ADAM17) (between Ala-Val), as well as MMP-3, MMP-7, MMP-12, and MMP-17, but not for ADAM19, MMP-13, nor MMP-14. Similar substrates are also cleaved by ADAM10, ADAM8 and ADAM9, and MMP-1, -2, and -9. This quenched substrate is useful for TACE inhibitor screening and kinetic analysis. Ex: 328 nm, Em: 393 nm, although the following Ex/Em have been used: 320-340/400-420. Also available: OMNIMMP® Fluorogenic Control peptide (BML-P127).

Product Specification

Alternative Name:ADAM17 substrate
 
Sequence:Mca-Pro-Leu-Ala-Gln-Ala-Val-Dpa-Arg-Ser-Ser-Ser-Arg-NH2
[Mca=(7-methoxycoumarin-4-yl)acetyl; Dpa=N-3(2,4-dinitrophenyl)-L-α,β-diaminopropionyl]
 
Formula:C69H103N23O24
 
MW:1638.7
 
CAS:192723-42-5
 
Purity:≥96%
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 

Related Products

OMNIMMP® fluorogenic control 

140430-55-3, Synthetic., ≥98% (TLC) | Print as PDF
 
BML-P127-0001 1 mg 71.00 USD
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